BRD-K74840245_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

44 genes differentially expressed following the BRD-K74840245_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ARG2 arginase 2
BTG2 BTG family, member 2
CD38 CD38 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CXCL10 chemokine (C-X-C motif) ligand 10
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FAM69A family with sequence similarity 69, member A
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
MEST mesoderm specific transcript
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
ORC1 origin recognition complex, subunit 1
PLAU plasminogen activator, urokinase
PON3 paraoxonase 3
PSD3 pleckstrin and Sec7 domain containing 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TFRC transferrin receptor

decreased expression

Symbol Name
BAMBI BMP and activin membrane-bound inhibitor
C6ORF62 chromosome 6 open reading frame 62
DLC1 DLC1 Rho GTPase activating protein
EGR3 early growth response 3
HOXA5 homeobox A5
IGFBP3 insulin-like growth factor binding protein 3
KLF4 Kruppel-like factor 4 (gut)
LAMC1 laminin, gamma 1 (formerly LAMB2)
MGLL monoglyceride lipase
NRIP1 nuclear receptor interacting protein 1
RAD51C RAD51 paralog C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLIT2 slit homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNPO1 transportin 1
ZMIZ1 zinc finger, MIZ-type containing 1