BRD-K74797618_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K74797618_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
CD163 CD163 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL11A1 collagen, type XI, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45A growth arrest and DNA-damage-inducible, alpha
HEPH hephaestin
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
MAGEA3 melanoma antigen family A3
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
TRIB1 tribbles pseudokinase 1
TUFT1 tuftelin 1
UST uronyl-2-sulfotransferase

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
CANT1 calcium activated nucleotidase 1
CD24 CD24 molecule
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYB561 cytochrome b561
ERBB4 erb-b2 receptor tyrosine kinase 4
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMGN3 high mobility group nucleosomal binding domain 3
KRT14 keratin 14, type I
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MREG melanoregulin
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAM peptidylglycine alpha-amidating monooxygenase
PAX5 paired box 5
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SEPP1 selenoprotein P, plasma, 1
SOX4 SRY (sex determining region Y)-box 4
SRSF1 serine/arginine-rich splicing factor 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
WFDC2 WAP four-disulfide core domain 2