BRD-K74797618_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K74797618_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ACOT13 acyl-CoA thioesterase 13
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATF3 activating transcription factor 3
CA1 carbonic anhydrase I
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CES1 carboxylesterase 1
CTSL cathepsin L
DEFA4 defensin, alpha 4, corticostatin
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
HBD hemoglobin, delta
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HPSE heparanase
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
KYNU kynureninase
MCUR1 mitochondrial calcium uniporter regulator 1
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
NQO1 NAD(P)H dehydrogenase, quinone 1
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PIR pirin (iron-binding nuclear protein)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TPM4 tropomyosin 4
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDK1 cyclin-dependent kinase 1
CLDN18 claudin 18
CX3CR1 chemokine (C-X3-C motif) receptor 1
EVL Enah/Vasp-like
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
HSPA8 heat shock 70kDa protein 8
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
LIG1 ligase I, DNA, ATP-dependent
LY6E lymphocyte antigen 6 complex, locus E
MUC1 mucin 1, cell surface associated
NFIB nuclear factor I/B
PAN2 PAN2 poly(A) specific ribonuclease subunit
PFKL phosphofructokinase, liver
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBA1A tubulin, alpha 1a
UBE2C ubiquitin-conjugating enzyme E2C