BRD-K74761218_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K74761218_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANXA6 annexin A6
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BST2 bone marrow stromal cell antigen 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CGA glycoprotein hormones, alpha polypeptide
CTSA cathepsin A
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
FAM107A family with sequence similarity 107, member A
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
GSTA4 glutathione S-transferase alpha 4
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KLHL21 kelch-like family member 21
KRT20 keratin 20, type I
LDHB lactate dehydrogenase B
LPCAT1 lysophosphatidylcholine acyltransferase 1
MSN moesin
MVP major vault protein
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NID2 nidogen 2 (osteonidogen)
OPN3 opsin 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PRSS3 protease, serine, 3
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
TKTL1 transketolase-like 1
TMEM45A transmembrane protein 45A
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATF5 activating transcription factor 5
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CBX3 chromobox homolog 3
CD58 CD58 molecule
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DRAM1 DNA-damage regulated autophagy modulator 1
ECT2 epithelial cell transforming 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GTF3A general transcription factor IIIA
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
KEAP1 kelch-like ECH-associated protein 1
MAPK6 mitogen-activated protein kinase 6
MDK midkine (neurite growth-promoting factor 2)
MLPH melanophilin
MRPL57 mitochondrial ribosomal protein L57
MRPS2 mitochondrial ribosomal protein S2
NOL11 nucleolar protein 11
NRIP1 nuclear receptor interacting protein 1
PMM2 phosphomannomutase 2
PRR7 proline rich 7 (synaptic)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPDEF SAM pointed domain containing ETS transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLK2 tousled-like kinase 2
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XBP1 X-box binding protein 1
ZMYM2 zinc finger, MYM-type 2