BRD-K74761218_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

403 genes differentially expressed following the BRD-K74761218_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD3 abhydrolase domain containing 3
ADD3 adducin 3 (gamma)
AIF1 allograft inflammatory factor 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
APLP1 amyloid beta (A4) precursor-like protein 1
AREG amphiregulin
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BTG3 BTG family, member 3
C14ORF132 chromosome 14 open reading frame 132
C1QB complement component 1, q subcomponent, B chain
C3AR1 complement component 3a receptor 1
C9ORF16 chromosome 9 open reading frame 16
CA4 carbonic anhydrase IV
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CD52 CD52 molecule
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES2 carboxylesterase 2
CFD complement factor D (adipsin)
CGA glycoprotein hormones, alpha polypeptide
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLEC3B C-type lectin domain family 3, member B
CLEC7A C-type lectin domain family 7, member A
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXORF57 chromosome X open reading frame 57
CYB5R1 cytochrome b5 reductase 1
CYBRD1 cytochrome b reductase 1
DAAM2 dishevelled associated activator of morphogenesis 2
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLX2 distal-less homeobox 2
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETHE1 ethylmalonic encephalopathy 1
FAM8A1 family with sequence similarity 8, member A1
FBXO9 F-box protein 9
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GCG glucagon
GDI1 GDP dissociation inhibitor 1
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
HBB hemoglobin, beta
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLX H2.0-like homeobox
HSBP1 heat shock factor binding protein 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPB11 heat shock protein family B (small), member 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
INA internexin neuronal intermediate filament protein, alpha
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JAG1 jagged 1
KCTD5 potassium channel tetramerization domain containing 5
KIF1A kinesin family member 1A
KRT17 keratin 17, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGMN legumain
LIMCH1 LIM and calponin homology domains 1
LOC100507397 uncharacterized LOC100507397
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MEA1 male-enhanced antigen 1
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICB MHC class I polypeptide-related sequence B
MIR22HG MIR22 host gene
MLF2 myeloid leukemia factor 2
MOSPD1 motile sperm domain containing 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MVP major vault protein
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM7 PDZ and LIM domain 7 (enigma)
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PERP PERP, TP53 apoptosis effector
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRAF2 PRA1 domain family, member 2
PRSS21 protease, serine, 21 (testisin)
PSPH phosphoserine phosphatase
PTCH1 patched 1
PTN pleiotrophin
PTRF polymerase I and transcript release factor
R3HDM4 R3H domain containing 4
RAD9A RAD9 homolog A (S. pombe)
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC3 syndecan 3
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SRI sorcin
SST somatostatin
STAB1 stabilin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBX3 T-box 3
TGFA transforming growth factor, alpha
THY1 Thy-1 cell surface antigen
TIGAR TP53 induced glycolysis regulatory phosphatase
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNS1 tensin 1
TSPAN4 tetraspanin 4
TUBA4A tubulin, alpha 4a
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VIM vimentin
VWA5A von Willebrand factor A domain containing 5A
WDR45 WD repeat domain 45
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)
YIPF3 Yip1 domain family, member 3
YPEL5 yippee-like 5 (Drosophila)
ZCCHC24 zinc finger, CCHC domain containing 24
ZDHHC11 zinc finger, DHHC-type containing 11
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADNP activity-dependent neuroprotector homeobox
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA2 annexin A2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMT1 acidic residue methyltransferase 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
B3GNT1
BAG3 BCL2-associated athanogene 3
BARD1 BRCA1 associated RING domain 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL6 B-cell CLL/lymphoma 6
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK19 cyclin-dependent kinase 19
CLTC clathrin, heavy chain (Hc)
CNOT4 CCR4-NOT transcription complex, subunit 4
CNOT7 CCR4-NOT transcription complex, subunit 7
COIL coilin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CUX1 cut-like homeobox 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
ELOVL2 ELOVL fatty acid elongase 2
ELOVL6 ELOVL fatty acid elongase 6
EPRS glutamyl-prolyl-tRNA synthetase
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FAM208A family with sequence similarity 208, member A
FAM60A family with sequence similarity 60, member A
FASN fatty acid synthase
FASTKD2 FAST kinase domains 2
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS isoleucyl-tRNA synthetase
IGF1R insulin-like growth factor 1 receptor
IRX5 iroquois homeobox 5
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
KRT15 keratin 15, type I
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
LPP LIM domain containing preferred translocation partner in lipoma
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY6E lymphocyte antigen 6 complex, locus E
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MBNL1 muscleblind-like splicing regulator 1
MED13 mediator complex subunit 13
MLH1 mutL homolog 1
MLPH melanophilin
MME membrane metallo-endopeptidase
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRPL12 mitochondrial ribosomal protein L12
MRPL42 mitochondrial ribosomal protein L42
MRPS28 mitochondrial ribosomal protein S28
MRPS30 mitochondrial ribosomal protein S30
MRPS35 mitochondrial ribosomal protein S35
MRPS7 mitochondrial ribosomal protein S7
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NOTCH2 notch 2
NPEPPS aminopeptidase puromycin sensitive
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUP37 nucleoporin 37kDa
NUP85 nucleoporin 85kDa
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP2 poly (ADP-ribose) polymerase 2
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PDLIM5 PDZ and LIM domain 5
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PDZK1 PDZ domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRRC2C proline-rich coiled-coil 2C
PRSS23 protease, serine, 23
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PUF60 poly-U binding splicing factor 60KDa
RAB14 RAB14, member RAS oncogene family
RAN RAN, member RAS oncogene family
RANBP2 RAN binding protein 2
RBMX RNA binding motif protein, X-linked
RCC1 regulator of chromosome condensation 1
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF139 ring finger protein 139
RPS4Y1 ribosomal protein S4, Y-linked 1
RREB1 ras responsive element binding protein 1
SCAF8 SR-related CTD-associated factor 8
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SET SET nuclear proto-oncogene
SETD5 SET domain containing 5
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFPQ splicing factor proline/glutamine-rich
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMC4 structural maintenance of chromosomes 4
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRPX2 sushi-repeat containing protein, X-linked 2
SRSF1 serine/arginine-rich splicing factor 1
SRSF5 serine/arginine-rich splicing factor 5
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYPL1 synaptophysin-like 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCERG1 transcription elongation regulator 1
TDP1 tyrosyl-DNA phosphodiesterase 1
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUBB tubulin, beta class I
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UCK2 uridine-cytidine kinase 2
UGCG UDP-glucose ceramide glucosyltransferase
USP3 ubiquitin specific peptidase 3
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VEZF1 vascular endothelial zinc finger 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
XPO1 exportin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38
ZHX2 zinc fingers and homeoboxes 2
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8
ZNF217 zinc finger protein 217