BRD-K74761218_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

268 genes differentially expressed following the BRD-K74761218_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCY9 adenylate cyclase 9
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD46 ankyrin repeat domain 46
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGAP29 Rho GTPase activating protein 29
BAMBI BMP and activin membrane-bound inhibitor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CCNG2 cyclin G2
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CDK19 cyclin-dependent kinase 19
CFD complement factor D (adipsin)
CHMP1B charged multivesicular body protein 1B
CIB1 calcium and integrin binding 1 (calmyrin)
CLDN10 claudin 10
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CPD carboxypeptidase D
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXADR coxsackie virus and adenovirus receptor
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DGKA diacylglycerol kinase, alpha 80kDa
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSTN destrin (actin depolymerizing factor)
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPAS1 endothelial PAS domain protein 1
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM107A family with sequence similarity 107, member A
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSN gelsolin
GUSBP11 glucuronidase, beta pseudogene 11
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIPK1 homeodomain interacting protein kinase 1
HIST1H1C histone cluster 1, H1c
HN1 hematological and neurological expressed 1
HOOK2 hook microtubule-tethering protein 2
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL32 interleukin 32
INHBA inhibin, beta A
ITM2A integral membrane protein 2A
JAG1 jagged 1
JUN jun proto-oncogene
KIAA0226L KIAA0226-like
KIAA0922 KIAA0922
LAPTM5 lysosomal protein transmembrane 5
LIPA lipase A, lysosomal acid, cholesterol esterase
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPIN1 lipin 1
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MFAP4 microfibrillar-associated protein 4
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NGRN neugrin, neurite outgrowth associated
NLRP2 NLR family, pyrin domain containing 2
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAT ornithine aminotransferase
OSBPL8 oxysterol binding protein-like 8
OSR2 odd-skipped related transciption factor 2
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCP4 Purkinje cell protein 4
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLA2G15 phospholipase A2, group XV
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLS1 plastin 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX2 peroxiredoxin 2
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB29 RAB29, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
S100A14 S100 calcium binding protein A14
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPW1 selenoprotein W, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTSSA serine palmitoyltransferase, small subunit A
SST somatostatin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK17A serine/threonine kinase 17a
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
AQP9 aquaporin 9
ATF1 activating transcription factor 1
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CDCA3 cell division cycle associated 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLEC2B C-type lectin domain family 2, member B
COL5A2 collagen, type V, alpha 2
CPVL carboxypeptidase, vitellogenic-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
DEK DEK proto-oncogene
DIO2 deiodinase, iodothyronine, type II
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
EFS embryonal Fyn-associated substrate
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GRB14 growth factor receptor-bound protein 14
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
HOXA10 homeobox A10
HOXB2 homeobox B2
HOXB7 homeobox B7
HOXC6 homeobox C6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM3 interferon induced transmembrane protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LDLR low density lipoprotein receptor
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MSL1 male-specific lethal 1 homolog (Drosophila)
MTA1 metastasis associated 1
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
PARP2 poly (ADP-ribose) polymerase 2
PAX8 paired box 8
PDHX pyruvate dehydrogenase complex, component X
PGLS 6-phosphogluconolactonase
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PLXNB2 plexin B2
PRR7 proline rich 7 (synaptic)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
SCD5 stearoyl-CoA desaturase 5
SFRP1 secreted frizzled-related protein 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SOCS2 suppressor of cytokine signaling 2
SORBS3 sorbin and SH3 domain containing 3
SPAG7 sperm associated antigen 7
SPRY2 sprouty homolog 2 (Drosophila)
SRSF5 serine/arginine-rich splicing factor 5
STAG1 stromal antigen 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TPBG trophoblast glycoprotein
TRIP6 thyroid hormone receptor interactor 6
UBE3A ubiquitin protein ligase E3A
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
XIST X inactive specific transcript (non-protein coding)
ZBTB20 zinc finger and BTB domain containing 20