BRD-K74710236_VU0410183-2_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

232 genes differentially expressed following the BRD-K74710236_VU0410183-2_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AGR2 anterior gradient 2
AHCYL1 adenosylhomocysteinase-like 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
AQP8 aquaporin 8
AREG amphiregulin
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BACE2 beta-site APP-cleaving enzyme 2
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CCNG2 cyclin G2
CD24 CD24 molecule
CDK19 cyclin-dependent kinase 19
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CKB creatine kinase, brain
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DENND5A DENN/MADD domain containing 5A
DMD dystrophin
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
EGLN3 egl-9 family hypoxia-inducible factor 3
ENAH enabled homolog (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
ERO1L ERO1-like (S. cerevisiae)
FAM162A family with sequence similarity 162, member A
FHL1 four and a half LIM domains 1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLC glutamate-cysteine ligase, catalytic subunit
GOLM1 golgi membrane protein 1
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HK2 hexokinase 2
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INHBA inhibin, beta A
INHBB inhibin, beta B
INSR insulin receptor
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KIF5B kinesin family member 5B
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT17 keratin 17, type I
LRP4 low density lipoprotein receptor-related protein 4
LSR lipolysis stimulated lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALT1 MALT1 paracaspase
MAPT microtubule-associated protein tau
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NMB neuromedin B
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PIEZO2 piezo-type mechanosensitive ion channel component 2
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
QKI QKI, KH domain containing, RNA binding
RAB20 RAB20, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAB32 RAB32, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS1 regulator of G-protein signaling 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERTAD2 SERTA domain containing 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC2 stanniocalcin 2
TAGLN transgelin
TCF4 transcription factor 4
TFF1 trefoil factor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM100 transmembrane protein 100
TMEM2 transmembrane protein 2
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOX3 TOX high mobility group box family member 3
TTC3 tetratricopeptide repeat domain 3
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
APRT adenine phosphoribosyltransferase
AQP3 aquaporin 3 (Gill blood group)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
C20ORF27 chromosome 20 open reading frame 27
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CD320 CD320 molecule
CD38 CD38 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
DCXR dicarbonyl/L-xylulose reductase
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYD dihydropyrimidine dehydrogenase
ELOVL6 ELOVL fatty acid elongase 6
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FBP1 fructose-1,6-bisphosphatase 1
FJX1 four jointed box 1 (Drosophila)
FOLR1 folate receptor 1 (adult)
GLDC glycine dehydrogenase (decarboxylating)
GRWD1 glutamate-rich WD repeat containing 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HMGA1 high mobility group AT-hook 1
HMGB3 high mobility group box 3
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
ICAM2 intercellular adhesion molecule 2
ICT1 immature colon carcinoma transcript 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KIAA0100 KIAA0100
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
MDFIC MyoD family inhibitor domain containing
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPL20 mitochondrial ribosomal protein L20
MRPL3 mitochondrial ribosomal protein L3
MRPS12 mitochondrial ribosomal protein S12
MRPS34 mitochondrial ribosomal protein S34
MRPS7 mitochondrial ribosomal protein S7
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
OXLD1 oxidoreductase-like domain containing 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PARP1 poly (ADP-ribose) polymerase 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIB peptidylprolyl isomerase B (cyclophilin B)
RAN RAN, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RGS4 regulator of G-protein signaling 4
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RUVBL1 RuvB-like AAA ATPase 1
S100A8 S100 calcium binding protein A8
SERBP1 SERPINE1 mRNA binding protein 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SRGN serglycin
SRM spermidine synthase
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST7 suppression of tumorigenicity 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNGR2 synaptogyrin 2
TDO2 tryptophan 2,3-dioxygenase
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUSC3 tumor suppressor candidate 3
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VARS valyl-tRNA synthetase
WDR12 WD repeat domain 12