BRD-K74710236_-666_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K74710236_-666_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
COL3A1 collagen, type III, alpha 1
COL9A3 collagen, type IX, alpha 3
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EZR ezrin
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KRT10 keratin 10, type I
KRT17 keratin 17, type I
MSX1 msh homeobox 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDRG1 N-myc downstream regulated 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM2 PDZ and LIM domain 2 (mystique)
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PNMA2 paraneoplastic Ma antigen 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RCAN1 regulator of calcineurin 1
RNASE4 ribonuclease, RNase A family, 4
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ARMCX2 armadillo repeat containing, X-linked 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CD200 CD200 molecule
DPYSL3 dihydropyrimidinase-like 3
FAM129A family with sequence similarity 129, member A
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HSPA8 heat shock 70kDa protein 8
IGF1 insulin-like growth factor 1 (somatomedin C)
LXN latexin
MBOAT7 membrane bound O-acyltransferase domain containing 7
NELL2 NEL-like 2 (chicken)
PLN phospholamban
PYCARD PYD and CARD domain containing
RFC5 replication factor C (activator 1) 5, 36.5kDa
SCG5 secretogranin V
SMC1A structural maintenance of chromosomes 1A
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TARP TCR gamma alternate reading frame protein
XIST X inactive specific transcript (non-protein coding)