BRD-K74710236_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K74710236_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BAALC brain and acute leukemia, cytoplasmic
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CD200 CD200 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CERS6 ceramide synthase 6
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CPE carboxypeptidase E
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP3 dual specificity phosphatase 3
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESRP1 epithelial splicing regulatory protein 1
FAM69A family with sequence similarity 69, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FXYD3 FXYD domain containing ion transport regulator 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF15 growth differentiation factor 15
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HSPA13 heat shock protein 70kDa family, member 13
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKV4-1 immunoglobulin kappa variable 4-1
ISG20 interferon stimulated exonuclease gene 20kDa
KDM3A lysine (K)-specific demethylase 3A
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRDX4 peroxiredoxin 4
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSAT1 phosphoserine aminotransferase 1
RABGAP1L RAB GTPase activating protein 1-like
RALGDS ral guanine nucleotide dissociation stimulator
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
STC2 stanniocalcin 2
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TRAF5 TNF receptor-associated factor 5
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACSL1 acyl-CoA synthetase long-chain family member 1
ADIPOQ adiponectin, C1Q and collagen domain containing
AMIGO2 adhesion molecule with Ig-like domain 2
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CD24 CD24 molecule
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EMP1 epithelial membrane protein 1
FBLN1 fibulin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FPGS folylpolyglutamate synthase
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HOXA10 homeobox A10
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KIF20A kinesin family member 20A
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEIS2 Meis homeobox 2
MMP7 matrix metallopeptidase 7
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAX8 paired box 8
PLK1 polo-like kinase 1
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A2 S100 calcium binding protein A2
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TLR4 toll-like receptor 4