BRD-K74623475_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K74623475_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
ANK2 ankyrin 2, neuronal
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CAT catalase
CBS cystathionine-beta-synthase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL9A3 collagen, type IX, alpha 3
CPE carboxypeptidase E
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EPRS glutamyl-prolyl-tRNA synthetase
GAGE3 G antigen 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNAS GNAS complex locus
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
MAGEA3 melanoma antigen family A3
MARS methionyl-tRNA synthetase
METTL7A methyltransferase like 7A
MMP12 matrix metallopeptidase 12
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPOX protoporphyrinogen oxidase
PSAT1 phosphoserine aminotransferase 1
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TGFBR3 transforming growth factor, beta receptor III
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CKS2 CDC28 protein kinase regulatory subunit 2
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FOSL1 FOS-like antigen 1
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
HMGA2 high mobility group AT-hook 2
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
LY86 lymphocyte antigen 86
LYPD1 LY6/PLAUR domain containing 1
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS2 mitochondrial ribosomal protein S2
MTERF3 mitochondrial transcription termination factor 3
PLAT plasminogen activator, tissue
PRSS23 protease, serine, 23
PTDSS1 phosphatidylserine synthase 1
RGS4 regulator of G-protein signaling 4
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SRGN serglycin
SYPL1 synaptophysin-like 1
TFPI2 tissue factor pathway inhibitor 2
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1