BRD-K74486276_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K74486276_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
C1RL complement component 1, r subcomponent-like
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CDH13 cadherin 13
CFB complement factor B
CHRDL1 chordin-like 1
CLDN3 claudin 3
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DPP4 dipeptidyl-peptidase 4
EIF5A eukaryotic translation initiation factor 5A
EPHA4 EPH receptor A4
EXT1 exostosin glycosyltransferase 1
F11R F11 receptor
FAM129A family with sequence similarity 129, member A
FOXG1 forkhead box G1
FSD1 fibronectin type III and SPRY domain containing 1
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GSDMB gasdermin B
HOXA10 homeobox A10
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
INSIG1 insulin induced gene 1
LAPTM4B lysosomal protein transmembrane 4 beta
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100505650 uncharacterized LOC100505650
LTB lymphotoxin beta (TNF superfamily, member 3)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MEIS2 Meis homeobox 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSN moesin
NDP Norrie disease (pseudoglioma)
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCLO piccolo presynaptic cytomatrix protein
PCP4 Purkinje cell protein 4
PERP PERP, TP53 apoptosis effector
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PON2 paraoxonase 2
PRAME preferentially expressed antigen in melanoma
RAB29 RAB29, member RAS oncogene family
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS4 regulator of G-protein signaling 4
RNF167 ring finger protein 167
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
STMN2 stathmin 2
SV2A synaptic vesicle glycoprotein 2A
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TRIM2 tripartite motif containing 2

decreased expression

Symbol Name
AGR2 anterior gradient 2
CCND1 cyclin D1
CDA cytidine deaminase
CRISP3 cysteine-rich secretory protein 3
CTSG cathepsin G
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EHD1 EH-domain containing 1
FST follistatin
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPX2 glutathione peroxidase 2
IGL immunoglobulin lambda locus
KCTD12 potassium channel tetramerization domain containing 12
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MARCKS myristoylated alanine-rich protein kinase C substrate
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NIP7 NIP7, nucleolar pre-rRNA processing protein
PCDH9 protocadherin 9
PPIF peptidylprolyl isomerase F
RALGDS ral guanine nucleotide dissociation stimulator
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAC3D1 SAC3 domain containing 1
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SEPP1 selenoprotein P, plasma, 1
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAGLN transgelin
TATDN2 TatD DNase domain containing 2
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
TIMP3 TIMP metallopeptidase inhibitor 3
TRAM1 translocation associated membrane protein 1