BRD-K74486276_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K74486276_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOB aldolase B, fructose-bisphosphate
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ASPH aspartate beta-hydroxylase
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFD complement factor D (adipsin)
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
ELOVL6 ELOVL fatty acid elongase 6
F13A1 coagulation factor XIII, A1 polypeptide
FADS2 fatty acid desaturase 2
FDPS farnesyl diphosphate synthase
FN1 fibronectin 1
FSD1 fibronectin type III and SPRY domain containing 1
GLRX glutaredoxin (thioltransferase)
HEPH hephaestin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IL32 interleukin 32
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KRT20 keratin 20, type I
KRT23 keratin 23, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS4 lectin, galactoside-binding, soluble, 4
MFAP2 microfibrillar-associated protein 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MSN moesin
MTMR11 myotubularin related protein 11
MVP major vault protein
NELL2 NEL-like 2 (chicken)
NES nestin
PLAU plasminogen activator, urokinase
PLEK2 pleckstrin 2
PLIN2 perilipin 2
PON3 paraoxonase 3
PRSS8 protease, serine, 8
PSAP prosaposin
PYGL phosphorylase, glycogen, liver
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A6 S100 calcium binding protein A6
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SFRP1 secreted frizzled-related protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SYT1 synaptotagmin I
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
TPM2 tropomyosin 2 (beta)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TWF2 twinfilin actin binding protein 2
VIM vimentin
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ARMT1 acidic residue methyltransferase 1
ATF5 activating transcription factor 5
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CCNA2 cyclin A2
CDC6 cell division cycle 6
CEP55 centrosomal protein 55kDa
CXCL13 chemokine (C-X-C motif) ligand 13
GINS2 GINS complex subunit 2 (Psf2 homolog)
ICAM3 intercellular adhesion molecule 3
KIF14 kinesin family member 14
KRT10 keratin 10, type I
LIG1 ligase I, DNA, ATP-dependent
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
PPIF peptidylprolyl isomerase F
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
QDPR quinoid dihydropteridine reductase
RFC2 replication factor C (activator 1) 2, 40kDa
SHCBP1 SHC SH2-domain binding protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TACC3 transforming, acidic coiled-coil containing protein 3
TYMS thymidylate synthetase