BRD-K74430258_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K74430258_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CDK17 cyclin-dependent kinase 17
CFB complement factor B
CHMP4A charged multivesicular body protein 4A
CLIC4 chloride intracellular channel 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
DUSP3 dual specificity phosphatase 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
LUM lumican
LXN latexin
MANSC1 MANSC domain containing 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MCTP1 multiple C2 domains, transmembrane 1
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MX1 MX dynamin-like GTPase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
QPCT glutaminyl-peptide cyclotransferase
RSAD2 radical S-adenosyl methionine domain containing 2
S100A8 S100 calcium binding protein A8
SCG5 secretogranin V
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SULF1 sulfatase 1
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TXNDC9 thioredoxin domain containing 9
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ANXA6 annexin A6
AP2B1 adaptor-related protein complex 2, beta 1 subunit
BMP2 bone morphogenetic protein 2
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR4 fibroblast growth factor receptor 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R2 interleukin 1 receptor, type II
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PEG10 paternally expressed 10
PLBD1 phospholipase B domain containing 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PUF60 poly-U binding splicing factor 60KDa
SLIT2 slit homolog 2 (Drosophila)
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPATS2L spermatogenesis associated, serine-rich 2-like
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TUBB tubulin, beta class I
U2AF1 U2 small nuclear RNA auxiliary factor 1
VSNL1 visinin-like 1