BRD-K74305673_IMD 0354_SNUC4_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-K74305673_IMD 0354_SNUC4_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIPOQ adiponectin, C1Q and collagen domain containing
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CPB1 carboxypeptidase B1 (tissue)
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ENAH enabled homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FST follistatin
GEM GTP binding protein overexpressed in skeletal muscle
HSPA13 heat shock protein 70kDa family, member 13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IL7R interleukin 7 receptor
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
LYZ lysozyme
MEF2C myocyte enhancer factor 2C
MN1 meningioma (disrupted in balanced translocation) 1
MYOF myoferlin
NDNF neuron-derived neurotrophic factor
NET1 neuroepithelial cell transforming 1
NRIP1 nuclear receptor interacting protein 1
NXN nucleoredoxin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX1 pre-B-cell leukemia homeobox 1
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PLIN1 perilipin 1
PRKCI protein kinase C, iota
PTN pleiotrophin
RFC2 replication factor C (activator 1) 2, 40kDa
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AQP9 aquaporin 9
ATF5 activating transcription factor 5
ATP11B ATPase, class VI, type 11B
B3GNT1
CD1A CD1a molecule
CHI3L2 chitinase 3-like 2
CST6 cystatin E/M
DERA deoxyribose-phosphate aldolase (putative)
DYNLL1 dynein, light chain, LC8-type 1
ECI2 enoyl-CoA delta isomerase 2
FAM57A family with sequence similarity 57, member A
FCGBP Fc fragment of IgG binding protein
GRWD1 glutamate-rich WD repeat containing 1
HOXB7 homeobox B7
IL1R2 interleukin 1 receptor, type II
LGALS2 lectin, galactoside-binding, soluble, 2
LY6D lymphocyte antigen 6 complex, locus D
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
MSRB1 methionine sulfoxide reductase B1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRN1 neuritin 1
PGAM1 phosphoglycerate mutase 1 (brain)
PI3 peptidase inhibitor 3, skin-derived
POU4F1 POU class 4 homeobox 1
PTK2 protein tyrosine kinase 2
RNF167 ring finger protein 167
RPS11 ribosomal protein S11
S100A14 S100 calcium binding protein A14
SDC2 syndecan 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SPATS2L spermatogenesis associated, serine-rich 2-like
STX1A syntaxin 1A (brain)
TRAPPC3 trafficking protein particle complex 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)