BRD-K74305673_-666_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K74305673_-666_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHSP alpha hemoglobin stabilizing protein
ALAS2 5'-aminolevulinate synthase 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BPGM 2,3-bisphosphoglycerate mutase
CAPG capping protein (actin filament), gelsolin-like
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CORO1A coronin, actin binding protein, 1A
CRABP2 cellular retinoic acid binding protein 2
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYD dihydropyrimidine dehydrogenase
DUOX2 dual oxidase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
EXPH5 exophilin 5
FAM129A family with sequence similarity 129, member A
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATAD1 GATA zinc finger domain containing 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCLC glutamate-cysteine ligase, catalytic subunit
GPR183 G protein-coupled receptor 183
GSE1 Gse1 coiled-coil protein
H1F0 H1 histone family, member 0
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
KCTD12 potassium channel tetramerization domain containing 12
KLK10 kallikrein-related peptidase 10
KRT23 keratin 23, type I
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
METTL7A methyltransferase like 7A
MKRN1 makorin ring finger protein 1
MMP9 matrix metallopeptidase 9
MPZL2 myelin protein zero-like 2
MSMO1 methylsterol monooxygenase 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR1D2 nuclear receptor subfamily 1, group D, member 2
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PLBD1 phospholipase B domain containing 1
PRKCI protein kinase C, iota
PTN pleiotrophin
RAB33A RAB33A, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RBBP8 retinoblastoma binding protein 8
RFC2 replication factor C (activator 1) 2, 40kDa
RGS5 regulator of G-protein signaling 5
SERINC5 serine incorporator 5
SPARCL1 SPARC-like 1 (hevin)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TGFA transforming growth factor, alpha
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D3 TSC22 domain family, member 3
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
YEATS4 YEATS domain containing 4
ZFAND5 zinc finger, AN1-type domain 5
ZNF148 zinc finger protein 148
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ACTA2 actin, alpha 2, smooth muscle, aorta
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ANXA2P2 annexin A2 pseudogene 2
ANXA6 annexin A6
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
CCND1 cyclin D1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COMP cartilage oligomeric matrix protein
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CYR61 cysteine-rich, angiogenic inducer, 61
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNLT3 dynein, light chain, Tctex-type 3
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FBN1 fibrillin 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
FPGS folylpolyglutamate synthase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAA glucosidase, alpha; acid
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GAS1 growth arrest-specific 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPI glucose-6-phosphate isomerase
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
HEG1 heart development protein with EGF-like domains 1
HSPA8 heat shock 70kDa protein 8
HSPG2 heparan sulfate proteoglycan 2
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIF2C kinesin family member 2C
KRT18 keratin 18, type I
LAMP1 lysosomal-associated membrane protein 1
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LUM lumican
MAP1A microtubule-associated protein 1A
MAP7 microtubule-associated protein 7
MN1 meningioma (disrupted in balanced translocation) 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPDZ multiple PDZ domain protein
MRPL12 mitochondrial ribosomal protein L12
MRPS16 mitochondrial ribosomal protein S16
MSRB2 methionine sulfoxide reductase B2
MYL9 myosin, light chain 9, regulatory
NME1 NME/NM23 nucleoside diphosphate kinase 1
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NT5DC2 5'-nucleotidase domain containing 2
NUTF2 nuclear transport factor 2
ODC1 ornithine decarboxylase 1
PFKP phosphofructokinase, platelet
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB4 phospholipase C, beta 4
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRAF2 PRA1 domain family, member 2
PRDX4 peroxiredoxin 4
PRSS23 protease, serine, 23
RAB13 RAB13, member RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A13 S100 calcium binding protein A13
SEPT11 septin 11
SEPW1 selenoprotein W, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SNF8 SNF8, ESCRT-II complex subunit
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
SSFA2 sperm specific antigen 2
STAT1 signal transducer and activator of transcription 1, 91kDa
TACC1 transforming, acidic coiled-coil containing protein 1
TAGLN transgelin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRAM2 translocation associated membrane protein 2
TUBB6 tubulin, beta 6 class V
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
ZCCHC24 zinc finger, CCHC domain containing 24