BRD-K74305673_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K74305673_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG1 adhesion G protein-coupled receptor G1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATXN1 ataxin 1
BHLHE40 basic helix-loop-helix family, member e40
BRD4 bromodomain containing 4
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CPD carboxypeptidase D
CST6 cystatin E/M
CTH cystathionine gamma-lyase
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ESRP1 epithelial splicing regulatory protein 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL13RA1 interleukin 13 receptor, alpha 1
INSIG1 insulin induced gene 1
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT23 keratin 23, type I
LARP6 La ribonucleoprotein domain family, member 6
LPAR1 lysophosphatidic acid receptor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MBNL2 muscleblind-like splicing regulator 2
MID1IP1 MID1 interacting protein 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTPN3 protein tyrosine phosphatase, non-receptor type 3
QKI QKI, KH domain containing, RNA binding
RCAN1 regulator of calcineurin 1
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEPT10 septin 10
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
STC2 stanniocalcin 2
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VEZF1 vascular endothelial zinc finger 1
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD24 CD24 molecule
CD69 CD69 molecule
CDC25A cell division cycle 25A
CES1 carboxylesterase 1
GOLGA8A golgin A8 family, member A
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
H2AFV H2A histone family, member V
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
PI3 peptidase inhibitor 3, skin-derived
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RBM3 RNA binding motif (RNP1, RRM) protein 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SEPW1 selenoprotein W, 1
SESN1 sestrin 1
SLPI secretory leukocyte peptidase inhibitor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
WFS1 Wolfram syndrome 1 (wolframin)