BRD-K73418978_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K73418978_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
ALDOB aldolase B, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANPEP alanyl (membrane) aminopeptidase
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLIC5 chloride intracellular channel 5
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CYTIP cytohesin 1 interacting protein
DEFA5 defensin, alpha 5, Paneth cell-specific
DLK1 delta-like 1 homolog (Drosophila)
FBXO21 F-box protein 21
FGL2 fibrinogen-like 2
FRY furry homolog (Drosophila)
GUSBP11 glucuronidase, beta pseudogene 11
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL17RB interleukin 17 receptor B
IL7R interleukin 7 receptor
MAGEA3 melanoma antigen family A3
MMP12 matrix metallopeptidase 12
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
PDZK1IP1 PDZK1 interacting protein 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
REG1A regenerating islet-derived 1 alpha
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SPON2 spondin 2, extracellular matrix protein
STAR steroidogenic acute regulatory protein
TARP TCR gamma alternate reading frame protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTN1 actinin, alpha 1
ASCC3 activating signal cointegrator 1 complex subunit 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CP ceruloplasmin (ferroxidase)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EBNA1BP2 EBNA1 binding protein 2
GSTP1 glutathione S-transferase pi 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HP haptoglobin
IGFBP4 insulin-like growth factor binding protein 4
IRS1 insulin receptor substrate 1
KPNB1 karyopherin (importin) beta 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NUP62 nucleoporin 62kDa
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SMS spermine synthase
SORBS3 sorbin and SH3 domain containing 3
SSB Sjogren syndrome antigen B (autoantigen La)
TOP2A topoisomerase (DNA) II alpha 170kDa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YME1L1 YME1-like 1 ATPase