BRD-K73395020_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K73395020_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLVRB biliverdin reductase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CD81 CD81 molecule
CECR5 cat eye syndrome chromosome region, candidate 5
CSTA cystatin A (stefin A)
DARS aspartyl-tRNA synthetase
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
FAM162A family with sequence similarity 162, member A
FAM57A family with sequence similarity 57, member A
FXYD3 FXYD domain containing ion transport regulator 3
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GPI glucose-6-phosphate isomerase
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
INSIG2 insulin induced gene 2
KDM3A lysine (K)-specific demethylase 3A
LOX lysyl oxidase
MXI1 MAX interactor 1, dimerization protein
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STC1 stanniocalcin 1
TMEM45A transmembrane protein 45A
TNIP1 TNFAIP3 interacting protein 1
TRIM22 tripartite motif containing 22
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AURKA aurora kinase A
CCNB2 cyclin B2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FRZB frizzled-related protein
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LAMB1 laminin, beta 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PBK PDZ binding kinase
PLK1 polo-like kinase 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)