BRD-K73293050_S1170_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-K73293050_S1170_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
AMDHD2 amidohydrolase domain containing 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2L13 BCL2-like 13 (apoptosis facilitator)
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CFB complement factor B
CFD complement factor D (adipsin)
COL11A1 collagen, type XI, alpha 1
CREG1 cellular repressor of E1A-stimulated genes 1
CTSA cathepsin A
CTSB cathepsin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DRAM1 DNA-damage regulated autophagy modulator 1
DSP desmoplakin
EIF4B eukaryotic translation initiation factor 4B
ENO2 enolase 2 (gamma, neuronal)
FBLN1 fibulin 1
FGFR4 fibroblast growth factor receptor 4
FTH1 ferritin, heavy polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GRN granulin
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
IFITM1 interferon induced transmembrane protein 1
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHDC2 kelch domain containing 2
KLHL9 kelch-like family member 9
KRT15 keratin 15, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPAR6 lysophosphatidic acid receptor 6
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
NEU1 sialidase 1 (lysosomal sialidase)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
ORAI3 ORAI calcium release-activated calcium modulator 3
PDE8B phosphodiesterase 8B
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PSAP prosaposin
RAB15 RAB15, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SLC22A18 solute carrier family 22, member 18
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SPP1 secreted phosphoprotein 1
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSKU tsukushi, small leucine rich proteoglycan
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
VWA5A von Willebrand factor A domain containing 5A
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARMCX2 armadillo repeat containing, X-linked 2
ASF1B anti-silencing function 1B histone chaperone
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
COL3A1 collagen, type III, alpha 1
CORO1A coronin, actin binding protein, 1A
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM64A family with sequence similarity 64, member A
FLG filaggrin
FLNB filamin B, beta
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
HJURP Holliday junction recognition protein
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
ITGB1BP1 integrin beta 1 binding protein 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NNMT nicotinamide N-methyltransferase
ODC1 ornithine decarboxylase 1
OLFM1 olfactomedin 1
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
PTX3 pentraxin 3, long
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RPL39L ribosomal protein L39-like
RRM2 ribonucleotide reductase M2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPAG5 sperm associated antigen 5
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBCB tubulin folding cofactor B
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TUBA4A tubulin, alpha 4a
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
ZMYM2 zinc finger, MYM-type 2