BRD-K73261812_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K73261812_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CUX1 cut-like homeobox 1
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSE1 Gse1 coiled-coil protein
HES1 hes family bHLH transcription factor 1
HPSE heparanase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
LGALS1 lectin, galactoside-binding, soluble, 1
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NEBL nebulette
NRCAM neuronal cell adhesion molecule
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SPRED2 sprouty-related, EVH1 domain containing 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
THBD thrombomodulin
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
YARS tyrosyl-tRNA synthetase
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
CCDC86 coiled-coil domain containing 86
CLTB clathrin, light chain B
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM3C family with sequence similarity 3, member C
HOXC6 homeobox C6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IL17RB interleukin 17 receptor B
KIF20A kinesin family member 20A
LY6D lymphocyte antigen 6 complex, locus D
MAN1A1 mannosidase, alpha, class 1A, member 1
PAM peptidylglycine alpha-amidating monooxygenase
PCNA proliferating cell nuclear antigen
RPL37A ribosomal protein L37a
S100A8 S100 calcium binding protein A8
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
TFRC transferrin receptor
THBS2 thrombospondin 2
TRIM29 tripartite motif containing 29
WISP2 WNT1 inducible signaling pathway protein 2