BRD-K73261812_-666_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K73261812_-666_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAST calpastatin
CBS cystathionine-beta-synthase
COL11A1 collagen, type XI, alpha 1
DDIT3 DNA-damage-inducible transcript 3
DPT dermatopontin
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
GARS glycyl-tRNA synthetase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
LGALS4 lectin, galactoside-binding, soluble, 4
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TARS threonyl-tRNA synthetase
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCNA1 cyclin A1
HP haptoglobin
IGFBP3 insulin-like growth factor binding protein 3
KRT17 keratin 17, type I
MAMLD1 mastermind-like domain containing 1
NDP Norrie disease (pseudoglioma)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPIF peptidylprolyl isomerase F
RGS1 regulator of G-protein signaling 1
SGK1 serum/glucocorticoid regulated kinase 1
TBC1D4 TBC1 domain family, member 4
TFPI2 tissue factor pathway inhibitor 2
TMEM45A transmembrane protein 45A
WNT5A wingless-type MMTV integration site family, member 5A