BRD-K73261812_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-K73261812_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CLDN3 claudin 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
FAM129A family with sequence similarity 129, member A
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GRB10 growth factor receptor-bound protein 10
H1FX H1 histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IGFBP3 insulin-like growth factor binding protein 3
ISG20 interferon stimulated exonuclease gene 20kDa
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MOCOS molybdenum cofactor sulfurase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
SARS seryl-tRNA synthetase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
ANKRD10 ankyrin repeat domain 10
AURKA aurora kinase A
CCNF cyclin F
COL3A1 collagen, type III, alpha 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
GALC galactosylceramidase
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GCLC glutamate-cysteine ligase, catalytic subunit
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
RPS11 ribosomal protein S11
SLPI secretory leukocyte peptidase inhibitor
WBP5 WW domain binding protein 5