BRD-K72895815_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K72895815_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AGO2 argonaute RISC catalytic component 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BMP6 bone morphogenetic protein 6
CCL5 chemokine (C-C motif) ligand 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSTB cystatin B (stefin B)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EML3 echinoderm microtubule associated protein like 3
EMP1 epithelial membrane protein 1
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FGF2 fibroblast growth factor 2 (basic)
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GNLY granulysin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HBEGF heparin-binding EGF-like growth factor
HMGA1 high mobility group AT-hook 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KYNU kynureninase
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAST4 microtubule associated serine/threonine kinase family member 4
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
PENK proenkephalin
PGD phosphogluconate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PLAUR plasminogen activator, urokinase receptor
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEC plectin
PPAP2B phosphatidic acid phosphatase type 2B
PRF1 perforin 1 (pore forming protein)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
QPCT glutaminyl-peptide cyclotransferase
RND3 Rho family GTPase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMOX spermine oxidase
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STEAP1 six transmembrane epithelial antigen of the prostate 1
TALDO1 transaldolase 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TRIB1 tribbles pseudokinase 1
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADCY9 adenylate cyclase 9
ADGRF5 adhesion G protein-coupled receptor F5
AEBP1 AE binding protein 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMT1 acidic residue methyltransferase 1
ASPN asporin
BMI1 BMI1 proto-oncogene, polycomb ring finger
C3 complement component 3
C7 complement component 7
CD24 CD24 molecule
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
ENOPH1 enolase-phosphatase 1
ESR1 estrogen receptor 1
FILIP1L filamin A interacting protein 1-like
GAS1 growth arrest-specific 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HP haptoglobin
IGFBP5 insulin-like growth factor binding protein 5
MAPT microtubule-associated protein tau
MGP matrix Gla protein
MXRA5 matrix-remodelling associated 5
MYH10 myosin, heavy chain 10, non-muscle
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLN phospholamban
PRR15L proline rich 15-like
PXDN peroxidasin
RPL31 ribosomal protein L31
SDC2 syndecan 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SUB1 SUB1 homolog (S. cerevisiae)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TNNT1 troponin T type 1 (skeletal, slow)
YME1L1 YME1-like 1 ATPase