BRD-K72703948_ZM-447439_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K72703948_ZM-447439_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AQP3 aquaporin 3 (Gill blood group)
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
BPHL biphenyl hydrolase-like (serine hydrolase)
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAST calpastatin
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CECR1 cat eye syndrome chromosome region, candidate 1
CHN1 chimerin 1
CKLF chemokine-like factor
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CTSS cathepsin S
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GAGE3 G antigen 3
GNG11 guanine nucleotide binding protein (G protein), gamma 11
H2BFS H2B histone family, member S (pseudogene)
HEATR1 HEAT repeat containing 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HPRT1 hypoxanthine phosphoribosyltransferase 1
IDO1 indoleamine 2,3-dioxygenase 1
KIF14 kinesin family member 14
KRAS Kirsten rat sarcoma viral oncogene homolog
LRRC8D leucine rich repeat containing 8 family, member D
LY75 lymphocyte antigen 75
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAL mal, T-cell differentiation protein
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
METTL7A methyltransferase like 7A
MMP1 matrix metallopeptidase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NOV nephroblastoma overexpressed
NRN1 neuritin 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PPAP2B phosphatidic acid phosphatase type 2B
PRSS21 protease, serine, 21 (testisin)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RABGGTB Rab geranylgeranyltransferase, beta subunit
RGCC regulator of cell cycle
RPL31 ribosomal protein L31
SELENBP1 selenium binding protein 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPRED2 sprouty-related, EVH1 domain containing 2
TOP1 topoisomerase (DNA) I
TUSC3 tumor suppressor candidate 3
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ASNS asparagine synthetase (glutamine-hydrolyzing)
BZW2 basic leucine zipper and W2 domains 2
CADM1 cell adhesion molecule 1
CD69 CD69 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CENPE centromere protein E, 312kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
HBB hemoglobin, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IGHM immunoglobulin heavy constant mu
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LTF lactotransferrin
LUM lumican
MET MET proto-oncogene, receptor tyrosine kinase
MX1 MX dynamin-like GTPase 1
MYBPC1 myosin binding protein C, slow type
NEBL nebulette
P3H2 prolyl 3-hydroxylase 2
PAPD7 PAP associated domain containing 7
PDE4DIP phosphodiesterase 4D interacting protein
PRPF4 pre-mRNA processing factor 4
RAD51C RAD51 paralog C
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC38A1 solute carrier family 38, member 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STOM stomatin
SYNE1 spectrin repeat containing, nuclear envelope 1
TFF3 trefoil factor 3 (intestinal)
TLE4 transducin-like enhancer of split 4
TSPYL5 TSPY-like 5
VCAM1 vascular cell adhesion molecule 1