BRD-K72636697_QL-X-138_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K72636697_QL-X-138_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
ATM ATM serine/threonine kinase
BCAS3 breast carcinoma amplified sequence 3
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEMIP cell migration inducing protein, hyaluronan binding
CYTH1 cytohesin 1
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DSG2 desmoglein 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ESR1 estrogen receptor 1
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FOXO3 forkhead box O3
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
KAT6B K(lysine) acetyltransferase 6B
KIAA1324 KIAA1324
KIZ kizuna centrosomal protein
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100272216 uncharacterized LOC100272216
LRRC17 leucine rich repeat containing 17
LXN latexin
MAN2A1 mannosidase, alpha, class 2A, member 1
MEIS1 Meis homeobox 1
MLPH melanophilin
MSLN mesothelin
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
MVP major vault protein
MXRA5 matrix-remodelling associated 5
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NEFH neurofilament, heavy polypeptide
NPIPB3 nuclear pore complex interacting protein family, member B3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDGFC platelet derived growth factor C
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PSPH phosphoserine phosphatase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS10 regulator of G-protein signaling 10
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SECISBP2L SECIS binding protein 2-like
SH3YL1 SH3 and SYLF domain containing 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC38A2 solute carrier family 38, member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPDEF SAM pointed domain containing ETS transcription factor
SVIL supervillin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TJP2 tight junction protein 2
TMPRSS3 transmembrane protease, serine 3
TXNIP thioredoxin interacting protein
URI1 URI1, prefoldin-like chaperone
USP34 ubiquitin specific peptidase 34
XIST X inactive specific transcript (non-protein coding)
ZCCHC6 zinc finger, CCHC domain containing 6
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CALR calreticulin
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CENPN centromere protein N
CENPU centromere protein U
CKS1B CDC28 protein kinase regulatory subunit 1B
COL1A2 collagen, type I, alpha 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EDNRB endothelin receptor type B
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FASN fatty acid synthase
FGFR3 fibroblast growth factor receptor 3
FOXG1 forkhead box G1
GAL galanin/GMAP prepropeptide
GNAS GNAS complex locus
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLT1B golgi transport 1B
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIST1H4C histone cluster 1, H4c
HSPA14 heat shock 70kDa protein 14
ICMT isoprenylcysteine carboxyl methyltransferase
IFRD2 interferon-related developmental regulator 2
IL1RN interleukin 1 receptor antagonist
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC59 leucine rich repeat containing 59
MAL mal, T-cell differentiation protein
MALT1 MALT1 paracaspase
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NFIB nuclear factor I/B
PCDH17 protocadherin 17
PI3 peptidase inhibitor 3, skin-derived
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RFC4 replication factor C (activator 1) 4, 37kDa
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC35B1 solute carrier family 35, member B1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TMEM47 transmembrane protein 47
TNC tenascin C
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
ZMIZ1 zinc finger, MIZ-type containing 1
ZWINT ZW10 interacting kinetochore protein