BRD-K72636697_QL-X-138_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

204 genes differentially expressed following the BRD-K72636697_QL-X-138_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AHNAK2 AHNAK nucleoprotein 2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
AREG amphiregulin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
C6ORF48 chromosome 6 open reading frame 48
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CRABP1 cellular retinoic acid binding protein 1
CST1 cystatin SN
CST4 cystatin S
DARS aspartyl-tRNA synthetase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DIAPH2 diaphanous-related formin 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSG2 desmoglein 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5 eukaryotic translation initiation factor 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA8A golgin A8 family, member A
HBP1 HMG-box transcription factor 1
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HOMER2 homer scaffolding protein 2
IDS iduronate 2-sulfatase
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KAT6B K(lysine) acetyltransferase 6B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT17 keratin 17, type I
KYNU kynureninase
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LAMP2 lysosomal-associated membrane protein 2
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
OLFM4 olfactomedin 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP6 poly (ADP-ribose) polymerase family, member 6
PCM1 pericentriolar material 1
PLCB4 phospholipase C, beta 4
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
PTHLH parathyroid hormone-like hormone
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAP1GAP2 RAP1 GTPase activating protein 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RBM34 RNA binding motif protein 34
REG1A regenerating islet-derived 1 alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RPS17 ribosomal protein S17
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC1 serine incorporator 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
STAG2 stromal antigen 2
STC1 stanniocalcin 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TFE3 transcription factor binding to IGHM enhancer 3
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNXB tenascin XB
TRD T cell receptor delta locus
TSC22D3 TSC22 domain family, member 3
TTC17 tetratricopeptide repeat domain 17
UFM1 ubiquitin-fold modifier 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ADI1 acireductone dioxygenase 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARG2 arginase 2
ATAD2 ATPase family, AAA domain containing 2
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNE1 cyclin E1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CIT citron rho-interacting serine/threonine kinase
CNN3 calponin 3, acidic
COL1A1 collagen, type I, alpha 1
CRELD2 cysteine-rich with EGF-like domains 2
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EBP emopamil binding protein (sterol isomerase)
EMP2 epithelial membrane protein 2
ENDOD1 endonuclease domain containing 1
ENO1 enolase 1, (alpha)
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLM1 golgi membrane protein 1
GPX3 glutathione peroxidase 3
GYS1 glycogen synthase 1 (muscle)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LDLR low density lipoprotein receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGED1 melanoma antigen family D1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MELK maternal embryonic leucine zipper kinase
MLANA melan-A
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
NNMT nicotinamide N-methyltransferase
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
RAD51C RAD51 paralog C
RHOB ras homolog family member B
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
SPINK5 serine peptidase inhibitor, Kazal type 5
SQLE squalene epoxidase
STMN1 stathmin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TFDP1 transcription factor Dp-1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TSPAN8 tetraspanin 8
UNC13B unc-13 homolog B (C. elegans)
WDR61 WD repeat domain 61