BRD-K72636697_QL-X-138_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K72636697_QL-X-138_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
ANXA3 annexin A3
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
C6ORF48 chromosome 6 open reading frame 48
CAPN3 calpain 3, (p94)
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CLGN calmegin
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
FHL2 four and a half LIM domains 2
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KLF5 Kruppel-like factor 5 (intestinal)
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPDC1 neural proliferation, differentiation and control, 1
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB4 phospholipase C, beta 4
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIRT3 sirtuin 3
SOX9 SRY (sex determining region Y)-box 9
STX1A syntaxin 1A (brain)
TFPI2 tissue factor pathway inhibitor 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D1 TSC22 domain family, member 1
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
VEGFC vascular endothelial growth factor C
YBX3 Y box binding protein 3

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARMT1 acidic residue methyltransferase 1
CCNA2 cyclin A2
CCND3 cyclin D3
CCNE2 cyclin E2
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
HCLS1 hematopoietic cell-specific Lyn substrate 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF20A kinesin family member 20A
LPL lipoprotein lipase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MREG melanoregulin
MSX1 msh homeobox 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSIP1 PC4 and SFRS1 interacting protein 1
RAD51C RAD51 paralog C
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHCBP1 SHC SH2-domain binding protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNX10 sorting nexin 10
SQRDL sulfide quinone reductase-like (yeast)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
VLDLR very low density lipoprotein receptor