BRD-K72451865_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K72451865_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABLIM1 actin binding LIM protein 1
ACTA1 actin, alpha 1, skeletal muscle
ACTN1 actinin, alpha 1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CBS cystathionine-beta-synthase
CD163 CD163 molecule
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CERS6 ceramide synthase 6
COPA coatomer protein complex, subunit alpha
CTSL cathepsin L
DAPK1 death-associated protein kinase 1
DARS aspartyl-tRNA synthetase
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EIF1 eukaryotic translation initiation factor 1
ELANE elastase, neutrophil expressed
EMX2 empty spiracles homeobox 2
EPRS glutamyl-prolyl-tRNA synthetase
FNDC3B fibronectin type III domain containing 3B
GAB2 GRB2-associated binding protein 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LAMP3 lysosomal-associated membrane protein 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAP7 microtubule-associated protein 7
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARS asparaginyl-tRNA synthetase
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PAWR PRKC, apoptosis, WT1, regulator
PHGDH phosphoglycerate dehydrogenase
PRTN3 proteinase 3
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAP1GAP RAP1 GTPase activating protein
RSL1D1 ribosomal L1 domain containing 1
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SARS seryl-tRNA synthetase
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TGFBI transforming growth factor, beta-induced, 68kDa
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TTN titin
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ADI1 acireductone dioxygenase 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPN centromere protein N
CFH complement factor H
CMC2 C-x(9)-C motif containing 2
COX7B cytochrome c oxidase subunit VIIb
CXCL12 chemokine (C-X-C motif) ligand 12
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCH1 GTP cyclohydrolase 1
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
H2AFX H2A histone family, member X
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HOXC6 homeobox C6
HSPB11 heat shock protein family B (small), member 11
ISOC1 isochorismatase domain containing 1
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MICB MHC class I polypeptide-related sequence B
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFA4 NDUFA4, mitochondrial complex associated
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OLFM1 olfactomedin 1
PCNA proliferating cell nuclear antigen
PLIN1 perilipin 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SC5D sterol-C5-desaturase
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLBP stem-loop binding protein
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPG small nuclear ribonucleoprotein polypeptide G
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TK1 thymidine kinase 1, soluble
WDR61 WD repeat domain 61
ZWINT ZW10 interacting kinetochore protein