BRD-K72451865_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K72451865_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP9 A kinase (PRKA) anchor protein 9
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
C10ORF10 chromosome 10 open reading frame 10
CAST calpastatin
CCNG2 cyclin G2
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
FHL2 four and a half LIM domains 2
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGFBP3 insulin-like growth factor binding protein 3
IL1RAP interleukin 1 receptor accessory protein
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
LGALS3 lectin, galactoside-binding, soluble, 3
MPO myeloperoxidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NT5E 5'-nucleotidase, ecto (CD73)
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
RIOK3 RIO kinase 3
SFRP1 secreted frizzled-related protein 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
TTN titin
USP3 ubiquitin specific peptidase 3
VCAN versican
VEGFA vascular endothelial growth factor A
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AURKA aurora kinase A
AURKB aurora kinase B
BAG3 BCL2-associated athanogene 3
CCNB1 cyclin B1
COPS7A COP9 signalosome subunit 7A
CPE carboxypeptidase E
CXCL5 chemokine (C-X-C motif) ligand 5
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ELOVL6 ELOVL fatty acid elongase 6
EVI2A ecotropic viral integration site 2A
H2AFX H2A histone family, member X
HHEX hematopoietically expressed homeobox
HSPA1A heat shock 70kDa protein 1A
LMO2 LIM domain only 2 (rhombotin-like 1)
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MTF2 metal response element binding transcription factor 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUAK1 NUAK family, SNF1-like kinase, 1
PLXNC1 plexin C1
PSRC1 proline/serine-rich coiled-coil 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100P S100 calcium binding protein P
SCG5 secretogranin V
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPINK1 serine peptidase inhibitor, Kazal type 1
TMEM2 transmembrane protein 2
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)