BRD-K72414522_AZD-5438_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K72414522_AZD-5438_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOB aldolase B, fructose-bisphosphate
ANXA4 annexin A4
APOA2 apolipoprotein A-II
ASPN asporin
BHLHE40 basic helix-loop-helix family, member e40
CCND1 cyclin D1
COL11A1 collagen, type XI, alpha 1
CTSK cathepsin K
ECM1 extracellular matrix protein 1
EMP3 epithelial membrane protein 3
FABP1 fatty acid binding protein 1, liver
FBLN1 fibulin 1
FBXL12 F-box and leucine-rich repeat protein 12
FGFR3 fibroblast growth factor receptor 3
FLNA filamin A, alpha
FN1 fibronectin 1
GATA2 GATA binding protein 2
GPC3 glypican 3
HIST1H1C histone cluster 1, H1c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ISG15 ISG15 ubiquitin-like modifier
KLF4 Kruppel-like factor 4 (gut)
LEF1 lymphoid enhancer-binding factor 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MMP11 matrix metallopeptidase 11
MN1 meningioma (disrupted in balanced translocation) 1
MOXD1 monooxygenase, DBH-like 1
OPHN1 oligophrenin 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PIR pirin (iron-binding nuclear protein)
REG1A regenerating islet-derived 1 alpha
SPINK1 serine peptidase inhibitor, Kazal type 1
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UQCRH ubiquinol-cytochrome c reductase hinge protein
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
APLP2 amyloid beta (A4) precursor-like protein 2
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNF cyclin F
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CENPA centromere protein A
CLDN4 claudin 4
CSTA cystatin A (stefin A)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
EIF5 eukaryotic translation initiation factor 5
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IGKC immunoglobulin kappa constant
KIAA0355 KIAA0355
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
LAMP5 lysosomal-associated membrane protein family, member 5
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MNDA myeloid cell nuclear differentiation antigen
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
PEG10 paternally expressed 10
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SORBS2 sorbin and SH3 domain containing 2
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)