BRD-K72414522_AZD-5438_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K72414522_AZD-5438_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACSF2 acyl-CoA synthetase family member 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE41 basic helix-loop-helix family, member e41
BID BH3 interacting domain death agonist
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CA2 carbonic anhydrase II
CCNA1 cyclin A1
CD40 CD40 molecule, TNF receptor superfamily member 5
CDCP1 CUB domain containing protein 1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFB complement factor B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CRIP1 cysteine-rich protein 1 (intestinal)
CYBA cytochrome b-245, alpha polypeptide
DEGS1 delta(4)-desaturase, sphingolipid 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS1 fatty acid desaturase 1
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GAL galanin/GMAP prepropeptide
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GPC3 glypican 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HLA-DMA major histocompatibility complex, class II, DM alpha
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLK10 kallikrein-related peptidase 10
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
LY75 lymphocyte antigen 75
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MSLN mesothelin
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NPDC1 neural proliferation, differentiation and control, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCDH7 protocadherin 7
PDZK1IP1 PDZK1 interacting protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPIF peptidylprolyl isomerase F
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB40B RAB40B, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNGR2 synaptogyrin 2
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TSC22D1 TSC22 domain family, member 1
TSPAN1 tetraspanin 1
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADI1 acireductone dioxygenase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CCNF cyclin F
CD163 CD163 molecule
CDC42 cell division cycle 42
CDKN3 cyclin-dependent kinase inhibitor 3
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CETN3 centrin, EF-hand protein, 3
CIT citron rho-interacting serine/threonine kinase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPS8 epidermal growth factor receptor pathway substrate 8
FGF13 fibroblast growth factor 13
FOXO4 forkhead box O4
FZD7 frizzled class receptor 7
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPNMB glycoprotein (transmembrane) nmb
GPSM2 G-protein signaling modulator 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LMO3 LIM domain only 3 (rhombotin-like 2)
LUM lumican
MIR22HG MIR22 host gene
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
ODC1 ornithine decarboxylase 1
PEG10 paternally expressed 10
PFDN4 prefoldin subunit 4
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SEC61G Sec61 gamma subunit
SEPP1 selenoprotein P, plasma, 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SRSF3 serine/arginine-rich splicing factor 3
SS18 synovial sarcoma translocation, chromosome 18
TMEM50A transmembrane protein 50A
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB2A tubulin, beta 2A class IIa
TXNDC9 thioredoxin domain containing 9
UBE2S ubiquitin-conjugating enzyme E2S
XPO7 exportin 7
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)