BRD-K72414522_AZD-5438_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K72414522_AZD-5438_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIF1 allograft inflammatory factor 1
APOE apolipoprotein E
C6ORF48 chromosome 6 open reading frame 48
CALD1 caldesmon 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CFB complement factor B
CPM carboxypeptidase M
CXCL8 chemokine (C-X-C motif) ligand 8
CYC1 cytochrome c-1
ELOVL5 ELOVL fatty acid elongase 5
EPCAM epithelial cell adhesion molecule
FGFR3 fibroblast growth factor receptor 3
FKBP1A FK506 binding protein 1A, 12kDa
GMPR guanosine monophosphate reductase
GPX3 glutathione peroxidase 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS1 lectin, galactoside-binding, soluble, 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAOA monoamine oxidase A
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NMU neuromedin U
NRGN neurogranin (protein kinase C substrate, RC3)
PDE1A phosphodiesterase 1A, calmodulin-dependent
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PLA2G16 phospholipase A2, group XVI
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRAME preferentially expressed antigen in melanoma
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
QPCT glutaminyl-peptide cyclotransferase
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SST somatostatin
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
VCAN versican
VEGFA vascular endothelial growth factor A
VIM vimentin
XCL1 chemokine (C motif) ligand 1

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BARD1 BRCA1 associated RING domain 1
BCL7B B-cell CLL/lymphoma 7B
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CDK13 cyclin-dependent kinase 13
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
DAAM1 dishevelled associated activator of morphogenesis 1
DBF4 DBF4 zinc finger
DICER1 dicer 1, ribonuclease type III
EIF5 eukaryotic translation initiation factor 5
EXO1 exonuclease 1
FZD7 frizzled class receptor 7
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
JCHAIN joining chain of multimeric IgA and IgM
KRCC1 lysine-rich coiled-coil 1
MCM10 minichromosome maintenance complex component 10
PEG10 paternally expressed 10
POU2AF1 POU class 2 associating factor 1
PRDM2 PR domain containing 2, with ZNF domain
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM38 RNA binding motif protein 38
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SERTAD2 SERTA domain containing 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SULF1 sulfatase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TNPO1 transportin 1
UCK2 uridine-cytidine kinase 2
WEE1 WEE1 G2 checkpoint kinase
ZNF107 zinc finger protein 107
ZNF117 zinc finger protein 117