BRD-K72414522_AZD-5438_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K72414522_AZD-5438_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ANXA4 annexin A4
AREG amphiregulin
ASPH aspartate beta-hydroxylase
BECN1 beclin 1, autophagy related
BHLHE41 basic helix-loop-helix family, member e41
CCL20 chemokine (C-C motif) ligand 20
CD52 CD52 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFB complement factor B
CLEC3B C-type lectin domain family 3, member B
CTSE cathepsin E
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
ESR2 estrogen receptor 2 (ER beta)
FAR2 fatty acyl CoA reductase 2
FHL2 four and a half LIM domains 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPC3 glypican 3
GRB10 growth factor receptor-bound protein 10
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KRT18 keratin 18, type I
KRT6B keratin 6B, type II
LAMC2 laminin, gamma 2
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
LPIN1 lipin 1
MAP1B microtubule-associated protein 1B
MFAP5 microfibrillar associated protein 5
MMP7 matrix metallopeptidase 7
OBSL1 obscurin-like 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDZK1IP1 PDZK1 interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PGM1 phosphoglucomutase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G16 phospholipase A2, group XVI
PRNP prion protein
QPCT glutaminyl-peptide cyclotransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REG1A regenerating islet-derived 1 alpha
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSTA3 tissue specific transplantation antigen P35B
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WASF3 WAS protein family, member 3

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CAPN1 calpain 1, (mu/I) large subunit
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD14 CD14 molecule
CDCA3 cell division cycle associated 3
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CLDN3 claudin 3
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
EIF5A eukaryotic translation initiation factor 5A
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FLRT2 fibronectin leucine rich transmembrane protein 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GPNMB glycoprotein (transmembrane) nmb
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB2 homeobox B2
IL13RA2 interleukin 13 receptor, alpha 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
MKI67 marker of proliferation Ki-67
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRUNE prune exopolyphosphatase
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RDX radixin
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG5 sperm associated antigen 5
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN1 stathmin 1
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
TOP2A topoisomerase (DNA) II alpha 170kDa
TRMT5 tRNA methyltransferase 5
TTK TTK protein kinase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)