BRD-K72414522_AZD-5438_LNCAP_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K72414522_AZD-5438_LNCAP_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASPN asporin
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CXCL14 chemokine (C-X-C motif) ligand 14
DES desmin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPCAM epithelial cell adhesion molecule
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXF1 forkhead box F1
FRZB frizzled-related protein
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MCOLN1 mucolipin 1
PLS3 plastin 3
PNPLA6 patatin-like phospholipase domain containing 6
PRKCQ protein kinase C, theta
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCG2 secretogranin II
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3YL1 SH3 and SYLF domain containing 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPINK1 serine peptidase inhibitor, Kazal type 1
STAP2 signal transducing adaptor family member 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TNS1 tensin 1
TRBC1 T cell receptor beta constant 1
TSPAN8 tetraspanin 8
TUBB6 tubulin, beta 6 class V
VARS valyl-tRNA synthetase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADRB2 adrenoceptor beta 2, surface
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BCL6 B-cell CLL/lymphoma 6
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CCNG2 cyclin G2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
FCGBP Fc fragment of IgG binding protein
GIMAP4 GTPase, IMAP family member 4
GPER1 G protein-coupled estrogen receptor 1
HMOX1 heme oxygenase 1
JADE1 jade family PHD finger 1
LXN latexin
MCL1 myeloid cell leukemia 1
MT1X metallothionein 1X
NRN1 neuritin 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PUF60 poly-U binding splicing factor 60KDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SGCE sarcoglycan, epsilon
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SYT17 synaptotagmin XVII
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMP4 TIMP metallopeptidase inhibitor 4
TMEM100 transmembrane protein 100
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VGLL4 vestigial-like family member 4
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZIC1 Zic family member 1
ZNF217 zinc finger protein 217