BRD-K72414522_AZD-5438_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K72414522_AZD-5438_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BHLHE41 basic helix-loop-helix family, member e41
BPIFA1 BPI fold containing family A, member 1
CAPN6 calpain 6
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFB complement factor B
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLU clusterin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
F3 coagulation factor III (thromboplastin, tissue factor)
GOLGA8B golgin A8 family, member B
GPRC5B G protein-coupled receptor, class C, group 5, member B
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
LCN2 lipocalin 2
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
NPC1 Niemann-Pick disease, type C1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PRNP prion protein
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
PXDN peroxidasin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SYBU syntabulin (syntaxin-interacting)
TFF1 trefoil factor 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB2 tribbles pseudokinase 2
WT1 Wilms tumor 1
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCNA2 cyclin A2
CCNB1 cyclin B1
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CNPY3 canopy FGF signaling regulator 3
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEK DEK proto-oncogene
DEPDC1 DEP domain containing 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLX5 distal-less homeobox 5
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EGFR epidermal growth factor receptor
EMP2 epithelial membrane protein 2
ETV1 ets variant 1
FBLN1 fibulin 1
FOXD1 forkhead box D1
FOXM1 forkhead box M1
GLO1 glyoxalase I
H2AFX H2A histone family, member X
HAS2 hyaluronan synthase 2
HBB hemoglobin, beta
HMGB2 high mobility group box 2
HOXB2 homeobox B2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LMNB1 lamin B1
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLAC8 placenta-specific 8
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RNASEH2A ribonuclease H2, subunit A
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SDC1 syndecan 1
SFN stratifin
SLC38A2 solute carrier family 38, member 2
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
STMN1 stathmin 1
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
WNT5A wingless-type MMTV integration site family, member 5A