BRD-K72414522_AZD-5438_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K72414522_AZD-5438_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHCY adenosylhomocysteinase
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
BLMH bleomycin hydrolase
BTG3 BTG family, member 3
C3ORF52 chromosome 3 open reading frame 52
CCDC86 coiled-coil domain containing 86
CCL20 chemokine (C-C motif) ligand 20
CCNE1 cyclin E1
CDCP1 CUB domain containing protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
CSTB cystatin B (stefin B)
CTTN cortactin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DESI1 desumoylating isopeptidase 1
DHCR7 7-dehydrocholesterol reductase
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EREG epiregulin
EXOSC4 exosome component 4
FADS1 fatty acid desaturase 1
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
GRB10 growth factor receptor-bound protein 10
HK2 hexokinase 2
HSPH1 heat shock 105kDa/110kDa protein 1
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
LRPPRC leucine-rich pentatricopeptide repeat containing
MAP1B microtubule-associated protein 1B
MMP11 matrix metallopeptidase 11
MMP3 matrix metallopeptidase 3
NRCAM neuronal cell adhesion molecule
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPIF peptidylprolyl isomerase F
PSAT1 phosphoserine aminotransferase 1
PTGES prostaglandin E synthase
RAB31 RAB31, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRP1B ribosomal RNA processing 1B
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SRP72 signal recognition particle 72kDa
TFRC transferrin receptor
TMEM147 transmembrane protein 147
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM5 transmembrane protein 5
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ALCAM activated leukocyte cell adhesion molecule
ANGPT1 angiopoietin 1
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BLNK B-cell linker
BRD8 bromodomain containing 8
C1ORF115 chromosome 1 open reading frame 115
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAT catalase
CCNG2 cyclin G2
CD164 CD164 molecule, sialomucin
CDC20 cell division cycle 20
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
COG7 component of oligomeric golgi complex 7
CPA3 carboxypeptidase A3 (mast cell)
CRISP3 cysteine-rich secretory protein 3
CSTA cystatin A (stefin A)
CTBP2 C-terminal binding protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
FSTL1 follistatin-like 1
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GIMAP4 GTPase, IMAP family member 4
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HDAC6 histone deacetylase 6
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA10 homeobox A10
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGL immunoglobulin lambda locus
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
KLF2 Kruppel-like factor 2
KLHDC2 kelch domain containing 2
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LOXL1 lysyl oxidase-like 1
LPL lipoprotein lipase
LRP10 low density lipoprotein receptor-related protein 10
LYZ lysozyme
MAOB monoamine oxidase B
MAT2B methionine adenosyltransferase II, beta
MATN2 matrilin 2
MME membrane metallo-endopeptidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1H metallothionein 1H
MT1X metallothionein 1X
NDC80 NDC80 kinetochore complex component
NES nestin
NKX3-1 NK3 homeobox 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRP1 neuropilin 1
NUSAP1 nucleolar and spindle associated protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTTG1 pituitary tumor-transforming 1
RAB40B RAB40B, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RPA3 replication protein A3, 14kDa
S100A11 S100 calcium binding protein A11
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC38A2 solute carrier family 38, member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORBS1 sorbin and SH3 domain containing 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM14A transmembrane protein 14A
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM29 tripartite motif containing 29
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1