BRD-K72414522_AZD-5438_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K72414522_AZD-5438_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BMP2 bone morphogenetic protein 2
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CFB complement factor B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPT dermatopontin
EIF3M eukaryotic translation initiation factor 3, subunit M
EPCAM epithelial cell adhesion molecule
FHL1 four and a half LIM domains 1
GCH1 GTP cyclohydrolase 1
GGT1 gamma-glutamyltransferase 1
HK2 hexokinase 2
HOOK2 hook microtubule-tethering protein 2
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL32 interleukin 32
IL6 interleukin 6
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
NAAA N-acylethanolamine acid amidase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID2 nidogen 2 (osteonidogen)
NRIP1 nuclear receptor interacting protein 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRKCQ protein kinase C, theta
PSPH phosphoserine phosphatase
PTK2B protein tyrosine kinase 2 beta
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RNF144A ring finger protein 144A
SCG5 secretogranin V
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFN stratifin
SOD2 superoxide dismutase 2, mitochondrial
SRSF11 serine/arginine-rich splicing factor 11
STMN2 stathmin 2
TGFA transforming growth factor, alpha
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TSPAN7 tetraspanin 7
XIST X inactive specific transcript (non-protein coding)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AUTS2 autism susceptibility candidate 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAV2 caveolin 2
CCNA2 cyclin A2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CKS2 CDC28 protein kinase regulatory subunit 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ETV1 ets variant 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD7 frizzled class receptor 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB2 homeobox B2
HOXB7 homeobox B7
HOXC6 homeobox C6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INSIG1 insulin induced gene 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
LDLR low density lipoprotein receptor
LPAR1 lysophosphatidic acid receptor 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MET MET proto-oncogene, receptor tyrosine kinase
MMP1 matrix metallopeptidase 1
MSMO1 methylsterol monooxygenase 1
NDC80 NDC80 kinetochore complex component
PDGFA platelet-derived growth factor alpha polypeptide
PDGFD platelet derived growth factor D
PLK1 polo-like kinase 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PUF60 poly-U binding splicing factor 60KDa
PXDN peroxidasin
PYGB phosphorylase, glycogen; brain
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC38A2 solute carrier family 38, member 2
SMAGP small cell adhesion glycoprotein
SMC4 structural maintenance of chromosomes 4
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STMN1 stathmin 1
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM50A transmembrane protein 50A
TTK TTK protein kinase
TUBA1A tubulin, alpha 1a
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WDTC1 WD and tetratricopeptide repeats 1