BRD-K72414522_AZD-5438_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

233 genes differentially expressed following the BRD-K72414522_AZD-5438_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACO2 aconitase 2, mitochondrial
ADCY3 adenylate cyclase 3
ADGRL2 adhesion G protein-coupled receptor L2
AHCY adenosylhomocysteinase
AHNAK2 AHNAK nucleoprotein 2
APOE apolipoprotein E
ARL4C ADP-ribosylation factor-like 4C
BST2 bone marrow stromal cell antigen 2
CCND1 cyclin D1
CHGB chromogranin B
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CYB561 cytochrome b561
DACH1 dachshund family transcription factor 1
DALRD3 DALR anticodon binding domain containing 3
DEFB1 defensin, beta 1
ENO2 enolase 2 (gamma, neuronal)
ENOSF1 enolase superfamily member 1
EREG epiregulin
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GGCT gamma-glutamylcyclotransferase
GGT1 gamma-glutamyltransferase 1
GPC1 glypican 1
GPI glucose-6-phosphate isomerase
HOOK2 hook microtubule-tethering protein 2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KANK2 KN motif and ankyrin repeat domains 2
L1CAM L1 cell adhesion molecule
LAMA5 laminin, alpha 5
LAMB2 laminin, beta 2 (laminin S)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRN3 leucine rich repeat neuronal 3
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MTCL1 microtubule crosslinking factor 1
MUC16 mucin 16, cell surface associated
NFIB nuclear factor I/B
NPDC1 neural proliferation, differentiation and control, 1
NPY1R neuropeptide Y receptor Y1
NRCAM neuronal cell adhesion molecule
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NUP210 nucleoporin 210kDa
OBSL1 obscurin-like 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PRKCD protein kinase C, delta
PRR7 proline rich 7 (synaptic)
PRSS3 protease, serine, 3
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRO protein tyrosine phosphatase, receptor type, O
RAB31 RAB31, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAGD Ras-related GTP binding D
SCARB2 scavenger receptor class B, member 2
SCG2 secretogranin II
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHOX2 short stature homeobox 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A18 solute carrier family 22, member 18
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNX11 sorting nexin 11
SON SON DNA binding protein
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPTAN1 spectrin, alpha, non-erythrocytic 1
TKT transketolase
TMEM176B transmembrane protein 176B
TMEM97 transmembrane protein 97
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPP1 tripeptidyl peptidase I
TSPAN8 tetraspanin 8
UBE2G2 ubiquitin-conjugating enzyme E2G 2
WASF3 WAS protein family, member 3

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ADI1 acireductone dioxygenase 1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1ORF116 chromosome 1 open reading frame 116
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC92 coiled-coil domain containing 92
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDC25C cell division cycle 25C
CDCA3 cell division cycle associated 3
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CEP70 centrosomal protein 70kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKAP4 cytoskeleton-associated protein 4
CLC Charcot-Leyden crystal galectin
CNN3 calponin 3, acidic
COL1A1 collagen, type I, alpha 1
CREB1 cAMP responsive element binding protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
DENND1B DENN/MADD domain containing 1B
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EAPP E2F-associated phosphoprotein
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
FAM46C family with sequence similarity 46, member C
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO4 forkhead box O4
FST follistatin
GSTA1 glutathione S-transferase alpha 1
H1FX H1 histone family, member X
H2AFV H2A histone family, member V
HAPLN1 hyaluronan and proteoglycan link protein 1
HHEX hematopoietically expressed homeobox
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB3 high mobility group box 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISOC1 isochorismatase domain containing 1
JARID2 jumonji, AT rich interactive domain 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KLF2 Kruppel-like factor 2
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
LOC100129361
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MARCKSL1 MARCKS-like 1
MIR22HG MIR22 host gene
MOK MOK protein kinase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSMB microseminoprotein, beta-
MTSS1 metastasis suppressor 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NDC80 NDC80 kinetochore complex component
NDN necdin, melanoma antigen (MAGE) family member
NEK2 NIMA-related kinase 2
NKX3-1 NK3 homeobox 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
OSBPL8 oxysterol binding protein-like 8
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PNRC1 proline-rich nuclear receptor coactivator 1
PSAT1 phosphoserine aminotransferase 1
PSRC1 proline/serine-rich coiled-coil 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTTG1 pituitary tumor-transforming 1
RAP2B RAP2B, member of RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGCC regulator of cell cycle
SCGB1D2 secretoglobin, family 1D, member 2
SCRG1 stimulator of chondrogenesis 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SNAI2 snail family zinc finger 2
SQLE squalene epoxidase
SSR1 signal sequence receptor, alpha
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TLE4 transducin-like enhancer of split 4
TMEM123 transmembrane protein 123
TOP2A topoisomerase (DNA) II alpha 170kDa
TP63 tumor protein p63
TPM1 tropomyosin 1 (alpha)
TTK TTK protein kinase
TUBB2A tubulin, beta 2A class IIa
TXNDC9 thioredoxin domain containing 9
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VTCN1 V-set domain containing T cell activation inhibitor 1
WTAP Wilms tumor 1 associated protein
YBX3 Y box binding protein 3
ZBTB18 zinc finger and BTB domain containing 18