BRD-K72414522_AZD-5438_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K72414522_AZD-5438_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY3 adenylate cyclase 3
APP amyloid beta (A4) precursor protein
ARL4C ADP-ribosylation factor-like 4C
C3 complement component 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CDC25A cell division cycle 25A
CFB complement factor B
CLNS1A chloride channel, nucleotide-sensitive, 1A
CYB561 cytochrome b561
DUSP7 dual specificity phosphatase 7
EFNB2 ephrin-B2
EXOSC4 exosome component 4
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GPC3 glypican 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEBP1 heme binding protein 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA1A heat shock 70kDa protein 1A
IL32 interleukin 32
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KRT18 keratin 18, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MMP7 matrix metallopeptidase 7
MOCOS molybdenum cofactor sulfurase
MRPS30 mitochondrial ribosomal protein S30
MYH10 myosin, heavy chain 10, non-muscle
NOLC1 nucleolar and coiled-body phosphoprotein 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NUP210 nucleoporin 210kDa
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PFKL phosphofructokinase, liver
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLTP phospholipid transfer protein
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCH protein kinase C, eta
PRR7 proline rich 7 (synaptic)
RBM34 RNA binding motif protein 34
RBP1 retinol binding protein 1, cellular
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC12A8 solute carrier family 12, member 8
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMCO4 single-pass membrane protein with coiled-coil domains 4
TMEM97 transmembrane protein 97
TSPAN3 tetraspanin 3
TSTA3 tissue specific transplantation antigen P35B
TTC3 tetratricopeptide repeat domain 3
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKR1C1 aldo-keto reductase family 1, member C1
AMOTL2 angiomotin like 2
ANXA1 annexin A1
APOD apolipoprotein D
ARG1 arginase 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC5 baculoviral IAP repeat containing 5
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CCNG2 cyclin G2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDC25C cell division cycle 25C
CDCA3 cell division cycle associated 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
COX7B cytochrome c oxidase subunit VIIb
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CXCL12 chemokine (C-X-C motif) ligand 12
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ETV1 ets variant 1
FAM13A family with sequence similarity 13, member A
FST follistatin
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPM6A glycoprotein M6A
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPSM2 G-protein signaling modulator 2
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
HAL histidine ammonia-lyase
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HOXB7 homeobox B7
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INHBB inhibin, beta B
JARID2 jumonji, AT rich interactive domain 2
JUP junction plakoglobin
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM3A lysine (K)-specific demethylase 3A
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LITAF lipopolysaccharide-induced TNF factor
LPAR6 lysophosphatidic acid receptor 6
METTL7A methyltransferase like 7A
MGLL monoglyceride lipase
MGST3 microsomal glutathione S-transferase 3
MKI67 marker of proliferation Ki-67
MPC2 mitochondrial pyruvate carrier 2
NCAPD2 non-SMC condensin I complex, subunit D2
NDC80 NDC80 kinetochore complex component
NEFH neurofilament, heavy polypeptide
NFIB nuclear factor I/B
NLRP2 NLR family, pyrin domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
PAIP1 poly(A) binding protein interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PNRC1 proline-rich nuclear receptor coactivator 1
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTTG1 pituitary tumor-transforming 1
PXDN peroxidasin
RAD21 RAD21 homolog (S. pombe)
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SH3GL2 SH3-domain GRB2-like 2
SKAP2 src kinase associated phosphoprotein 2
SKP1 S-phase kinase-associated protein 1
SLC38A2 solute carrier family 38, member 2
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SPAG5 sperm associated antigen 5
SPARCL1 SPARC-like 1 (hevin)
SPINK5 serine peptidase inhibitor, Kazal type 5
SQRDL sulfide quinone reductase-like (yeast)
STMN1 stathmin 1
TCF4 transcription factor 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIB3 tribbles pseudokinase 3
TTK TTK protein kinase
TUBA1A tubulin, alpha 1a
UGP2 UDP-glucose pyrophosphorylase 2
VAMP8 vesicle-associated membrane protein 8
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)