BRD-K72414522_AZD-5438_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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88 genes differentially expressed following the BRD-K72414522_AZD-5438_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABLIM1 actin binding LIM protein 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA4 annexin A4
APLP2 amyloid beta (A4) precursor-like protein 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
C3ORF14 chromosome 3 open reading frame 14
CCL5 chemokine (C-C motif) ligand 5
CLU clusterin
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DFNA5 deafness, autosomal dominant 5
DHDDS dehydrodolichyl diphosphate synthase
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
FBLN1 fibulin 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GYS1 glycogen synthase 1 (muscle)
HNMT histamine N-methyltransferase
MXRA5 matrix-remodelling associated 5
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCP4 Purkinje cell protein 4
PGD phosphogluconate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PVALB parvalbumin
RAB31 RAB31, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SFN stratifin
SFTPB surfactant protein B
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VWA8 von Willebrand factor A domain containing 8

decreased expression

Symbol Name
BGN biglycan
CAB39 calcium binding protein 39
CCK cholecystokinin
CDH3 cadherin 3, type 1, P-cadherin (placental)
CKS2 CDC28 protein kinase regulatory subunit 2
COL9A3 collagen, type IX, alpha 3
CREB1 cAMP responsive element binding protein 1
CTBP2 C-terminal binding protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DLC1 DLC1 Rho GTPase activating protein
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DYNLL1 dynein, light chain, LC8-type 1
FOXC1 forkhead box C1
G0S2 G0/G1 switch 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HIST1H4C histone cluster 1, H4c
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
INPP5F inositol polyphosphate-5-phosphatase F
ITM2A integral membrane protein 2A
KLK10 kallikrein-related peptidase 10
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1M metallothionein 1M
NGRN neugrin, neurite outgrowth associated
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRKD3 protein kinase D3
RAP1GAP2 RAP1 GTPase activating protein 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RGCC regulator of cell cycle
RGS13 regulator of G-protein signaling 13
SCGB1D2 secretoglobin, family 1D, member 2
SNAI2 snail family zinc finger 2
SPRY4 sprouty homolog 4 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
UGCG UDP-glucose ceramide glucosyltransferase
USP6NL USP6 N-terminal like
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1