BRD-K72264770_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K72264770_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
AUTS2 autism susceptibility candidate 2
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CNPY3 canopy FGF signaling regulator 3
CREG1 cellular repressor of E1A-stimulated genes 1
CRLF1 cytokine receptor-like factor 1
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
EPRS glutamyl-prolyl-tRNA synthetase
F3 coagulation factor III (thromboplastin, tissue factor)
FLNB filamin B, beta
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2A myocyte enhancer factor 2A
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NREP neuronal regeneration related protein
NRN1 neuritin 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTCH1 patched 1
RCAN1 regulator of calcineurin 1
RIOK3 RIO kinase 3
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TES testin LIM domain protein
TMEM45A transmembrane protein 45A
TNIP1 TNFAIP3 interacting protein 1
TNNC1 troponin C type 1 (slow)
TPI1 triosephosphate isomerase 1
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
AMACR alpha-methylacyl-CoA racemase
ATF5 activating transcription factor 5
CCNF cyclin F
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
COL10A1 collagen, type X, alpha 1
CPB1 carboxypeptidase B1 (tissue)
DACH1 dachshund family transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL17RB interleukin 17 receptor B
LOC283683 uncharacterized LOC283683
LUC7L3 LUC7-like 3 (S. cerevisiae)
MRFAP1L1 Morf4 family associated protein 1-like 1
MXRA5 matrix-remodelling associated 5
NME5 NME/NM23 family member 5
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
SFRP4 secreted frizzled-related protein 4
SPON1 spondin 1, extracellular matrix protein
TRAPPC3 trafficking protein particle complex 3
WT1 Wilms tumor 1