BRD-K71935468_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K71935468_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
CDR2 cerebellar degeneration-related protein 2, 62kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GARS glycyl-tRNA synthetase
GAS1 growth arrest-specific 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GSN gelsolin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LCN2 lipocalin 2
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLA2G16 phospholipase A2, group XVI
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
S100P S100 calcium binding protein P
SAP30 Sin3A-associated protein, 30kDa
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOX9 SRY (sex determining region Y)-box 9
TGFBI transforming growth factor, beta-induced, 68kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSC22D3 TSC22 domain family, member 3
WARS tryptophanyl-tRNA synthetase
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YARS tyrosyl-tRNA synthetase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ALCAM activated leukocyte cell adhesion molecule
ANKRD10 ankyrin repeat domain 10
AUTS2 autism susceptibility candidate 2
B3GNT1
BCHE butyrylcholinesterase
CA2 carbonic anhydrase II
CCL5 chemokine (C-C motif) ligand 5
CCNG1 cyclin G1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CXADR coxsackie virus and adenovirus receptor
DDAH1 dimethylarginine dimethylaminohydrolase 1
DPYD dihydropyrimidine dehydrogenase
GPM6A glycoprotein M6A
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN3 high mobility group nucleosomal binding domain 3
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
KANK2 KN motif and ankyrin repeat domains 2
LMO3 LIM domain only 3 (rhombotin-like 2)
LPCAT1 lysophosphatidylcholine acyltransferase 1
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MREG melanoregulin
NQO1 NAD(P)H dehydrogenase, quinone 1
NREP neuronal regeneration related protein
NTS neurotensin
OXA1L oxidase (cytochrome c) assembly 1-like
OXTR oxytocin receptor
PODXL podocalyxin-like
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RFC2 replication factor C (activator 1) 2, 40kDa
RPL31 ribosomal protein L31
SESN1 sestrin 1
SFTPB surfactant protein B
SNN stannin
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X