BRD-K71935468_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K71935468_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
C6ORF62 chromosome 6 open reading frame 62
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EDNRA endothelin receptor type A
EIF5A eukaryotic translation initiation factor 5A
FMO1 flavin containing monooxygenase 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
INHBA inhibin, beta A
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP1 matrix metallopeptidase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZB1 marginal zone B and B1 cell-specific protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SFRP4 secreted frizzled-related protein 4
TXNIP thioredoxin interacting protein
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF5 activating transcription factor 5
AURKA aurora kinase A
B3GNT1
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CDC25B cell division cycle 25B
CTSH cathepsin H
EMP3 epithelial membrane protein 3
ERBB3 erb-b2 receptor tyrosine kinase 3
F12 coagulation factor XII (Hageman factor)
FNBP1 formin binding protein 1
HBB hemoglobin, beta
KIF20A kinesin family member 20A
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MET MET proto-oncogene, receptor tyrosine kinase
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PLK1 polo-like kinase 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTTG1 pituitary tumor-transforming 1
SALL2 spalt-like transcription factor 2
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2
SYNM synemin, intermediate filament protein
ZDHHC3 zinc finger, DHHC-type containing 3