BRD-K71879491_tretinoin_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K71879491_tretinoin_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACADVL acyl-CoA dehydrogenase, very long chain
ACP5 acid phosphatase 5, tartrate resistant
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
ASPN asporin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BEX1 brain expressed, X-linked 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD36 CD36 molecule (thrombospondin receptor)
COL6A1 collagen, type VI, alpha 1
CPD carboxypeptidase D
CTSK cathepsin K
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
EGFL6 EGF-like-domain, multiple 6
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM129A family with sequence similarity 129, member A
FGG fibrinogen gamma chain
FOXO3 forkhead box O3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNAS GNAS complex locus
GULP1 GULP, engulfment adaptor PTB domain containing 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
IGFBP3 insulin-like growth factor binding protein 3
KLHDC2 kelch domain containing 2
KRT13 keratin 13, type I
KRT4 keratin 4, type II
LCN2 lipocalin 2
LXN latexin
MFAP2 microfibrillar-associated protein 2
MLEC malectin
MX2 MX dynamin-like GTPase 2
NMU neuromedin U
NPC1 Niemann-Pick disease, type C1
NPTX1 neuronal pentraxin I
PEG10 paternally expressed 10
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
PRKCD protein kinase C, delta
PRSS23 protease, serine, 23
PTGIS prostaglandin I2 (prostacyclin) synthase
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAP1GAP RAP1 GTPase activating protein
RRAGD Ras-related GTP binding D
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SKAP2 src kinase associated phosphoprotein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TMPRSS4 transmembrane protease, serine 4
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TUBB2B tubulin, beta 2B class IIb
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
APOD apolipoprotein D
BAG3 BCL2-associated athanogene 3
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CAV2 caveolin 2
CCND2 cyclin D2
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
CRIP2 cysteine-rich protein 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DST dystonin
EGR3 early growth response 3
ENO1 enolase 1, (alpha)
EVL Enah/Vasp-like
FABP7 fatty acid binding protein 7, brain
GAS2L1 growth arrest-specific 2 like 1
GPM6A glycoprotein M6A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIST1H2BG histone cluster 1, H2bg
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA4L heat shock 70kDa protein 4-like
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IRX5 iroquois homeobox 5
JAG1 jagged 1
KIF14 kinesin family member 14
LAGE3 L antigen family, member 3
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MFAP3L microfibrillar-associated protein 3-like
MUC1 mucin 1, cell surface associated
NR4A3 nuclear receptor subfamily 4, group A, member 3
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PXDN peroxidasin
RCAN1 regulator of calcineurin 1
RHOC ras homolog family member C
RRM1 ribonucleotide reductase M1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SFN stratifin
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOSTDC1 sclerostin domain containing 1
SPDEF SAM pointed domain containing ETS transcription factor
SPTBN1 spectrin, beta, non-erythrocytic 1
STK17A serine/threonine kinase 17a
TM4SF1 transmembrane 4 L six family member 1
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
VBP1 von Hippel-Lindau binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon