BRD-K71799949_carbamazepine_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K71799949_carbamazepine_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASS1 argininosuccinate synthase 1
BHMT2 betaine--homocysteine S-methyltransferase 2
C10ORF10 chromosome 10 open reading frame 10
CD164 CD164 molecule, sialomucin
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CTSG cathepsin G
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F3 coagulation factor III (thromboplastin, tissue factor)
FKBP5 FK506 binding protein 5
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
HOXC6 homeobox C6
IFI44 interferon-induced protein 44
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KIAA0753 KIAA0753
LOX lysyl oxidase
LPL lipoprotein lipase
LTF lactotransferrin
MAOA monoamine oxidase A
MCL1 myeloid cell leukemia 1
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NREP neuronal regeneration related protein
PAM peptidylglycine alpha-amidating monooxygenase
PER1 period circadian clock 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCD protein kinase C, delta
PVALB parvalbumin
RALGDS ral guanine nucleotide dissociation stimulator
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD5 stearoyl-CoA desaturase 5
SCPEP1 serine carboxypeptidase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SSBP2 single-stranded DNA binding protein 2
SYBU syntabulin (syntaxin-interacting)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
TSC22D3 TSC22 domain family, member 3
WFDC2 WAP four-disulfide core domain 2
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANKRD10 ankyrin repeat domain 10
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARL4C ADP-ribosylation factor-like 4C
BAX BCL2-associated X protein
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CD9 CD9 molecule
CLU clusterin
COCH cochlin
COL4A2 collagen, type IV, alpha 2
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DPYSL3 dihydropyrimidinase-like 3
DUOX2 dual oxidase 2
DUSP3 dual specificity phosphatase 3
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GATA6 GATA binding protein 6
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GNPDA1 glucosamine-6-phosphate deaminase 1
GSPT2 G1 to S phase transition 2
HBEGF heparin-binding EGF-like growth factor
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL11 interleukin 11
LIF leukemia inhibitory factor
LXN latexin
MACF1 microtubule-actin crosslinking factor 1
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYRF myelin regulatory factor
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFM4 olfactomedin 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PRSS2 protease, serine, 2 (trypsin 2)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
REG3A regenerating islet-derived 3 alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SMAD3 SMAD family member 3
SMC1A structural maintenance of chromosomes 1A
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SYNJ2 synaptojanin 2
TBX3 T-box 3
TCEAL2 transcription elongation factor A (SII)-like 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
WARS tryptophanyl-tRNA synthetase
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
XYLT1 xylosyltransferase I