BRD-K71103788_DULOXETINE HYDROCHLORIDE_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K71103788_DULOXETINE HYDROCHLORIDE_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
CCR7 chemokine (C-C motif) receptor 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CST3 cystatin C
CYBRD1 cytochrome b reductase 1
CYTH1 cytohesin 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPP4 dipeptidyl-peptidase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP4 fatty acid binding protein 4, adipocyte
FBN2 fibrillin 2
G6PD glucose-6-phosphate dehydrogenase
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KDM5D lysine (K)-specific demethylase 5D
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PGD phosphogluconate dehydrogenase
PHGDH phosphoglycerate dehydrogenase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SELENBP1 selenium binding protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TPSAB1 tryptase alpha/beta 1
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ALB albumin
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CDCA4 cell division cycle associated 4
COL9A3 collagen, type IX, alpha 3
CXADR coxsackie virus and adenovirus receptor
DHRS2 dehydrogenase/reductase (SDR family) member 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENOPH1 enolase-phosphatase 1
HIST1H1C histone cluster 1, H1c
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KDM3A lysine (K)-specific demethylase 3A
LOC100505650 uncharacterized LOC100505650
LYPLA1 lysophospholipase I
MMP10 matrix metallopeptidase 10
MYO10 myosin X
NDRG1 N-myc downstream regulated 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCCB propionyl CoA carboxylase, beta polypeptide
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG4 sperm associated antigen 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SST somatostatin
TPD52 tumor protein D52
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1