BRD-K70792160_Akt inhibitor X_SW620_6.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_SW620_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BPHL biphenyl hydrolase-like (serine hydrolase)
CAV2 caveolin 2
CEP57 centrosomal protein 57kDa
COL1A2 collagen, type I, alpha 2
CXCL13 chemokine (C-X-C motif) ligand 13
DLD dihydrolipoamide dehydrogenase
EIF1AX eukaryotic translation initiation factor 1A, X-linked
IL2RG interleukin 2 receptor, gamma
KLF4 Kruppel-like factor 4 (gut)
LUM lumican
MKNK1 MAP kinase interacting serine/threonine kinase 1
NARF nuclear prelamin A recognition factor
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PLXNA1 plexin A1
RGCC regulator of cell cycle
S100A13 S100 calcium binding protein A13
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TFRC transferrin receptor
TP63 tumor protein p63
TRIB1 tribbles pseudokinase 1
UBE3C ubiquitin protein ligase E3C
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
CCP110 centriolar coiled coil protein 110kDa
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEP170 centrosomal protein 170kDa
CLDN3 claudin 3
COPS7A COP9 signalosome subunit 7A
CTGF connective tissue growth factor
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ESR1 estrogen receptor 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
KDM5D lysine (K)-specific demethylase 5D
LAMP5 lysosomal-associated membrane protein family, member 5
LRRC17 leucine rich repeat containing 17
NRGN neurogranin (protein kinase C substrate, RC3)
PTX3 pentraxin 3, long
RBP1 retinol binding protein 1, cellular
RGS4 regulator of G-protein signaling 4
SFRP1 secreted frizzled-related protein 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPON1 spondin 1, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
TGFBI transforming growth factor, beta-induced, 68kDa