BRD-K70771662_11K-629S_NEU_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K70771662_11K-629S_NEU_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BIK BCL2-interacting killer (apoptosis-inducing)
CBS cystathionine-beta-synthase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSNK1E casein kinase 1, epsilon
CSRP1 cysteine and glycine-rich protein 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPHA3 EPH receptor A3
FST follistatin
GLS glutaminase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
KLK10 kallikrein-related peptidase 10
KRT23 keratin 23, type I
LCN2 lipocalin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP12 matrix metallopeptidase 12
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PTPRE protein tyrosine phosphatase, receptor type, E
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TBC1D4 TBC1 domain family, member 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
WFDC2 WAP four-disulfide core domain 2
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHNAK2 AHNAK nucleoprotein 2
CANT1 calcium activated nucleotidase 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CD36 CD36 molecule (thrombospondin receptor)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLU clusterin
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
ECM1 extracellular matrix protein 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
HBD hemoglobin, delta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
LRRC17 leucine rich repeat containing 17
MELK maternal embryonic leucine zipper kinase
MPC2 mitochondrial pyruvate carrier 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY1R neuropeptide Y receptor Y1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPA3 replication protein A3, 14kDa
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
TCF4 transcription factor 4
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)