BRD-K70748405_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K70748405_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CA12 carbonic anhydrase XII
CAST calpastatin
CCDC86 coiled-coil domain containing 86
CDK6 cyclin-dependent kinase 6
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHMP4A charged multivesicular body protein 4A
CHN2 chimerin 2
CKB creatine kinase, brain
CLIC4 chloride intracellular channel 4
CPM carboxypeptidase M
DCLK1 doublecortin-like kinase 1
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPP4 dipeptidyl-peptidase 4
FAM134B family with sequence similarity 134, member B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB6 homeobox B6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
ITM2C integral membrane protein 2C
KCNK3 potassium channel, two pore domain subfamily K, member 3
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
L1CAM L1 cell adhesion molecule
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSLN mesothelin
MSMB microseminoprotein, beta-
MTSS1 metastasis suppressor 1
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFML2A olfactomedin-like 2A
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PID1 phosphotyrosine interaction domain containing 1
PON2 paraoxonase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RAD21 RAD21 homolog (S. pombe)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
RTN2 reticulon 2
SDC2 syndecan 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SNAI2 snail family zinc finger 2
SNX13 sorting nexin 13
SOD2 superoxide dismutase 2, mitochondrial
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM100 transmembrane protein 100
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TROVE2 TROVE domain family, member 2
TSPAN12 tetraspanin 12
TUSC3 tumor suppressor candidate 3
VEGFA vascular endothelial growth factor A
WDR7 WD repeat domain 7

decreased expression

Symbol Name
AGR2 anterior gradient 2
AK4 adenylate kinase 4
ANXA3 annexin A3
APOA1 apolipoprotein A-I
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BST2 bone marrow stromal cell antigen 2
C2CD2 C2 calcium-dependent domain containing 2
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP4 cytoskeleton-associated protein 4
CLIC3 chloride intracellular channel 3
CLU clusterin
COL5A1 collagen, type V, alpha 1
CRCT1 cysteine-rich C-terminal 1
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
DHCR7 7-dehydrocholesterol reductase
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMBT1 deleted in malignant brain tumors 1
ECM1 extracellular matrix protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FLNA filamin A, alpha
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
HOPX HOP homeobox
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
KYNU kynureninase
LAMP5 lysosomal-associated membrane protein family, member 5
LDLR low density lipoprotein receptor
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEIS1 Meis homeobox 1
MGAM maltase-glucoamylase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSMO1 methylsterol monooxygenase 1
MUC1 mucin 1, cell surface associated
NEBL nebulette
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NQO1 NAD(P)H dehydrogenase, quinone 1
PEBP1 phosphatidylethanolamine binding protein 1
PIP prolactin-induced protein
PODXL podocalyxin-like
PROM1 prominin 1
QDPR quinoid dihydropteridine reductase
RDX radixin
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A12 S100 calcium binding protein A12
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SELL selectin L
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SPINK5 serine peptidase inhibitor, Kazal type 5
SQLE squalene epoxidase
TLR4 toll-like receptor 4
TSTA3 tissue specific transplantation antigen P35B
VWF von Willebrand factor