BRD-K70714754_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K70714754_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CD40 CD40 molecule, TNF receptor superfamily member 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF5A eukaryotic translation initiation factor 5A
GDF15 growth differentiation factor 15
GREM1 gremlin 1, DAN family BMP antagonist
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
H1F0 H1 histone family, member 0
H2AFV H2A histone family, member V
HBD hemoglobin, delta
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INSIG1 insulin induced gene 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LAMP1 lysosomal-associated membrane protein 1
LEF1 lymphoid enhancer-binding factor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OSBPL10 oxysterol binding protein-like 10
PLIN2 perilipin 2
PRDX2 peroxiredoxin 2
RAD23B RAD23 homolog B (S. cerevisiae)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPON2 spondin 2, extracellular matrix protein
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UROD uroporphyrinogen decarboxylase
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ASCL1 achaete-scute family bHLH transcription factor 1
C2CD5 C2 calcium-dependent domain containing 5
CD36 CD36 molecule (thrombospondin receptor)
COL5A2 collagen, type V, alpha 2
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
EMP1 epithelial membrane protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FAM46A family with sequence similarity 46, member A
FST follistatin
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLUL glutamate-ammonia ligase
HAS2 hyaluronan synthase 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLF10 Kruppel-like factor 10
KRT23 keratin 23, type I
MX2 MX dynamin-like GTPase 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP2 NLR family, pyrin domain containing 2
NPR3 natriuretic peptide receptor 3
PFKP phosphofructokinase, platelet
PIP prolactin-induced protein
PLAGL1 pleiomorphic adenoma gene-like 1
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SELL selectin L
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFF3 trefoil factor 3 (intestinal)
TPPP3 tubulin polymerization-promoting protein family member 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMYND11 zinc finger, MYND-type containing 11